Seroatlas · Human Serome Atlas

EDEM1

ER degradation-enhancing alpha-mannosidase-like protein 1

Also known as: EDEM, EDEM1_HUMAN, KIAA0212

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q92611
Gene: EDEM1
Ensembl: ENSG00000134109
Chromosome: 3
Canonical length: 657 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Endoplasmic reticulum,Aggresome

OverviewNCBI Gene

Enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity and misfolded protein binding activity. Involved in positive regulation of retrograde protein transport, ER to cytosol; protein targeting to ER; and proteolysis involved in protein catabolic process. Located in aggresome and endoplasmic reticulum quality control compartment. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

657 residues, UniProt reviewed canonical sequence.

>Q92611|EDEM1
     1  MQWRALVLGL VLLRLGLHGV LWLVFGLGPS MGFYQRFPLS FGFQRLRSPD GPASPTSGPV
    61  GRPGGVSGPS WLQPPGTGAA QSPRKAPRRP GPGMCGPANW GYVLGGRGRG PDEYEKRYSG
   121  AFPPQLRAQM RDLARGMFVF GYDNYMAHAF PQDELNPIHC RGRGPDRGDP SNLNINDVLG
   181  NYSLTLVDAL DTLAIMGNSS EFQKAVKLVI NTVSFDKDST VQVFEATIRV LGSLLSAHRI
   241  ITDSKQPFGD MTIKDYDNEL LYMAHDLAVR LLPAFENTKT GIPYPRVNLK TGVPPDTNNE
   301  TCTAGAGSLL VEFGILSRLL GDSTFEWVAR RAVKALWNLR SNDTGLLGNV VNIQTGHWVG
   361  KQSGLGAGLD SFYEYLLKSY ILFGEKEDLE MFNAAYQSIQ NYLRRGREAC NEGEGDPPLY
   421  VNVNMFSGQL MNTWIDSLQA FFPGLQVLIG DVEDAICLHA FYYAIWKRYG ALPERYNWQL
   481  QAPDVLFYPL RPELVESTYL LYQATKNPFY LHVGMDILQS LEKYTKVKCG YATLHHVIDK
   541  STEDRMESFF LSETCKYLYL LFDEDNPVHK SGTRYMFTTE GHIVSVDEHL RELPWKEFFS
   601  EEGGQDQGGK SVHRPKPHEL KVINSSSNCN RVPDERRYSL PLKSIYMRQI DQMVGLI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EDEM1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 74 nTPM

Expression across tissuesHPA

Tissue

thymus: 74 nTPM
bone marrow: 63 nTPM
liver: 56 nTPM
tonsil: 40 nTPM
lymph node: 39 nTPM
appendix: 30 nTPM

Single-cell type

neutrophil progenitors: 202 nCPM
plasma cells: 192 nCPM
cdc: 166 nCPM
alveolar cells type 2: 135 nCPM
monocytes: 117 nCPM
neutrophils: 109 nCPM

Immune cell

plasmacytoid DC: 7.5 nTPM
memory B-cell: 6.7 nTPM
T-reg: 6.7 nTPM
memory CD4 T-cell: 6 nTPM
MAIT T-cell: 5.7 nTPM
naive CD4 T-cell: 5.2 nTPM

Brain region

thalamus: 18 nTPM
medulla oblongata: 17 nTPM
hypothalamus: 17 nTPM
cerebral cortex: 17 nTPM
white matter: 17 nTPM
basal ganglia: 17 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about EDEM1.

Disease | ImmuneIEDB

Conditions an epitope on EDEM1 was assayed in.

systemic lupus erythematosus B cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.09
gnomAD pLI: 0
gnomAD missense Z: 0.37
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EDEM1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EDEM1 as an antibody target. Whether an autoantibody or antibody against EDEM1 could matter depends on whether native EDEM1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EDEM1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EDEM1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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