Seroatlas · Human Serome Atlas

DENND4C

DENN domain-containing protein 4C

Also known as: bA513M16.3, C9orf55, C9orf55B, DEN4C_HUMAN, FLJ20686, RAB10GEF

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5VZ89
Gene: DENND4C
Ensembl: ENSG00000137145
Chromosome: 9
Canonical length: 1909 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Golgi apparatus,Vesicles,Cytosol

OverviewNCBI Gene

Enables guanyl-nucleotide exchange factor activity. Predicted to be involved in cellular response to insulin stimulus; protein localization to plasma membrane; and regulation of Rab protein signal transduction. Located in Golgi apparatus and cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1909 residues, UniProt reviewed canonical sequence.

>Q5VZ89|DENND4C
     1  MIEDKGPRVT DYFVVAGLTD TSTLLDQEIN RLDTKSTGPK APITDIAIII KSAGETVPEG
    61  YTCVEATPSA LQANLNYGSL KSPELFLCYK RGRDKPPLTD IGVLYEGKER LIPGCEVILA
   121  TPYGRCANVN NSSTTSQRIF ITYRRAPPVR PQNSLAVTDI CVIVTSKGET PPHTFCKVDK
   181  NLNCGMWGSS VFLCYKKSVP ASNAIAYKAG LIFRYPEEDY ESFPLSESDV PLFCLPMGAT
   241  IECWDPETKY PLPVFSTFVL TGSSAKKVYG AAIQFYEPYS RELLSEKQLM HLGLLTPVER
   301  KMVSKSINTN KCICLLSHWP FFEAFRKFLM FIYKLSVSGP HPLPIEKHIS HFMQNIPFPS
   361  PQRPRILVQL SVHDALILSQ PVSTPLPLSG ANFSTLLMNL GPENCATLLL FVLLESKILL
   421  HSLRPAVLTG VAEAVVAMIF PFQWQCPYIP LCPLSLAAVL SAPLPFIVGV DSRYFDLHDP
   481  PQDVVCIDLD TNMLYVSDEK KNMNWKQLPK KPCKNLLSTL KKLYPQLSSV HQKTQEGSAI
   541  DMTPIEADFS WQKKMTQLEM EIQEAFLRFM ASILKGYRTY LRPITEAPSN KATAADSLFD
   601  RQGFLKSRDR AYAKFYTLLS KTQIFIRFIE ECSFVSDKDT GLAFFDDCIE KLFPDKGTEK
   661  TDKVDFDSAE DTRLIELDDS QKSEHTVFIM PPEPPPDDGK DLSPKYSYKY FPRLDLKLFD
   721  RPQELKLCFS RHPTGNSITK SPPLMAKRTK QEIKTAHKLA KRCYTNPPQW AKCLFSHCYS
   781  LWFICLPAYV RVSHPKVRAL QQAYDVLIKM RKTDVDPLDE VCYRVVMQLC GLWGHPVLAV
   841  RVLFEMKTAR IKPNAITYGY YNKVVLESPW PSSTRSGIFL WTKVRNVVRG LAQFRQPLKK
   901  TVQRSQVSSI SGGQSDQGYG SKDELIKDDA EIHVPEEQAA RELITKTKMQ TEEVCDASAI
   961  VAKHSQPSPE PHSPTEPPAW GSSIVKVPSG IFDVNSRKSS TGSISNVLFS TQDPVEDAVF
  1021  GEATNLKKNG DRGEKRQKHF PERSCSFSSE SRAGMLLKKS SLDSNSSEMA IMMGADAKIL
  1081  TAALTCPKTS LLHIARTHSF ENVSCHLPDS RTCMSESTWN PEHRSSPVPE MLEESQELLE
  1141  PVVDDVPKTT ATVDTYESLL SDSNSNQSRD LKTVSKDLRN KRSSLYGIAK VVQREDVETG
  1201  LDPLSLLATE CTGGKTPDSE DKLFSPVIAR NLADEIESYM NLKSPLGSKS SSMELHREEN
  1261  RESGMTTAFI HALERRSSLP LDHGSPAQEN PESEKSSPAV SRSKTFTGRF KQQTPSRTHK
  1321  ERSTSLSALV RSSPHGSLGS VVNSLSGLKL DNILSGPKID VLKSGMKQAA TVASKMWVAV
  1381  ASAYSYSDDE EETNRDYSFP AGLEDHILGE NISPNTSISG LVPSELTQSN TSLGSSSSSG
  1441  DVGKLHYPTG EVPFPRGMKG QDFEKSDHGS SQNTSMSSIY QNCAMEVLMS SCSQCRACGA
  1501  LVYDEEIMAG WTADDSNLNT ACPFCKSNFL PLLNIEFKDL RGSASFFLKP STSGDSLQSG
  1561  SIPLANESLE HKPVSSLAEP DLINFMDFPK HNQIITEETG SAVEPSDEIK RASGDVQTMK
  1621  ISSVPNSLSK RNVSLTRSHS VGGPLQNIDF TQRPFHGIST VSLPNSLQEV VDPLGKRPNP
  1681  PPVSVPYLSP LVLRKELESL LENEGDQVIH TSSFINQHPI IFWNLVWYFR RLDLPSNLPG
  1741  LILTSEHCNE GVQLPLSSLS QDSKLVYIQL LWDNINLHQE PREPLYVSWR NFNSEKKSSL
  1801  LSEEQQETST LVETIRQSIQ HNNVLKPINL LSQQMKPGMK RQRSLYREIL FLSLVSLGRE
  1861  NIDIEAFDNE YGIAYNSLSS EILERLQKID APPSASVEWC RKCFGAPLI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DENND4C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 28 nTPM

Expression across tissuesHPA

Tissue

skin: 28 nTPM
duodenum: 24 nTPM
small intestine: 21 nTPM
breast: 20 nTPM
stomach: 19 nTPM
rectum: 19 nTPM

Single-cell type

sertoli cells: 430 nCPM
macrophages: 313 nCPM
fibro-adipogenic progenitors: 308 nCPM
mast cells: 305 nCPM
cytotrophoblasts: 303 nCPM
foveolar cells: 295 nCPM

Immune cell

basophil: 8.3 nTPM
MAIT T-cell: 7 nTPM
NK-cell: 6.5 nTPM
memory CD8 T-cell: 5.5 nTPM
gdT-cell: 5.4 nTPM
naive CD8 T-cell: 5 nTPM

Brain region

cerebellum: 37 nTPM
choroid plexus: 24 nTPM
thalamus: 23 nTPM
basal ganglia: 22 nTPM
cerebral cortex: 21 nTPM
white matter: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.45
gnomAD pLI: 0
gnomAD missense Z: -0.65
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

guanyl-nucleotide exchange factor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DENND4C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DENND4C as an antibody target. Whether an autoantibody or antibody against DENND4C could matter depends on whether native DENND4C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DENND4C is annotated at the cell surface, where native DENND4C is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label DENND4C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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