Seroatlas · Human Serome Atlas

PAGE1

P antigen family member 1

Also known as: CT16.3, GAGE-9, GAGEB1, PAGE-1, PAGE1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75459
Gene: PAGE1
Ensembl: ENSG00000068985
Chromosome: X
Canonical length: 146 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli fibrillar center,Mitochondria

OverviewNCBI Gene

This gene belongs to a family of genes that are expressed in a variety of tumors but not in normal tissues, except for the testis. Unlike the other gene family members, this gene does not encode an antigenic peptide. Nothing is presently known about the function of this protein. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

146 residues, UniProt reviewed canonical sequence.

>O75459|PAGE1
     1  MGFLRRLIYR RRPMIYVESS EESSDEQPDE VESPTQSQDS TPAEEREDEG ASAAQGQEPE
    61  ADSQELVQPK TGCELGDGPD TKRVCLRNEE QMKLPAEGPE PEADSQEQVH PKTGCERGDG
   121  PDVQELGLPN PEEVKTPEED EGQSQP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PAGE1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.72
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

testis: 17 nTPM
epididymis: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM

Single-cell type

early primary spermatocytes: 268 nCPM
differentiating spermatogonia: 204 nCPM
undifferentiated spermatogonia: 36 nCPM
late spermatids: 3.3 nCPM
peritubular myoid cells: 2.6 nCPM
early spermatids: 1.7 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.53
gnomAD pLI: 0.82
gnomAD missense Z: -0.13
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Phosphoprotein

InteractionsUniProt · HPA

Protein binding partners of PAGE1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

DDX49

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PAGE1 as an antibody target. Whether an autoantibody or antibody against PAGE1 could matter depends on whether native PAGE1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PAGE1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PAGE1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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