SKI/SNO/DAC Dachshund homology domain

Definition

This entry represents a domain known as the Dachshund homology domain (DHD) that is about 100 amino acids long and found in members of Ski/Sno family. This domain contains a conserved CLPQ motif. The c-ski proto-oncogene has been shown to influence proliferation, morphological transformation and myogenic differentiation PMID:7999783. Sno, a Ski proto-oncogene homologue, is expressed in two isoforms and plays a role in the response to proliferation stimuli. Dachshund also contains this domain. It is involved in various aspects of development [[cite:PMID:7821215],[cite:PMID:11290302]]. The SKI-DHD adopts a mixed alpha/beta structure which includes features found in the forkhead/winged-helix family of DNA binding proteins, although SKI-DHD is not a DNA binding domain PMID:15130471.

7 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (7 proteins: gene, accession, name)

• DACH1
• DACH2
• SKI
• SKIDA1
• SKIL
• SKOR1
• SKOR2