TAMALIN
Protein TAMALIN
Also known as: GRASP, GRASP_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q7Z6J2
- Gene
- TAMALIN
- Ensembl
- ENSG00000161835
- Chromosome
- 12
- Canonical length
- 395 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nuclear bodies,Vesicles
OverviewNCBI Gene
This gene encodes a protein that functions as a molecular scaffold, linking receptors, including group 1 metabotropic glutamate receptors, to neuronal proteins. The encoded protein contains conserved domains, including a leucine zipper sequence, PDZ domain and a C-terminal PDZ-binding motif. Alternately spliced transcript variants have been observed for this gene.[provided by RefSeq, Dec 2012]
Canonical amino-acid sequenceUniProt
395 residues, UniProt reviewed canonical sequence.
>Q7Z6J2|TAMALIN
1 MTLRRLRKLQ QKEEAAATPD PAARTPDSEV APAAPVPTPG PPAAAATPGP PADELYAALE
61 DYHPAELYRA LAVSGGTLPR RKGSGFRWKN LSQSPEQQRK VLTLEKEDNQ TFGFEIQTYG
121 LHHREEQRVE MVTFVCRVHE SSPAQLAGLT PGDTIASVNG LNVEGIRHRE IVDIIKASGN
181 VLRLETLYGT SIRKAELEAR LQYLKQTLYE KWGEYRSLMV QEQRLVHGLV VKDPSIYDTL
241 ESVRSCLYGA GLLPGSLPFG PLLAVPGRPR GGARRARGDA DDAVYHTCFF GDSEPPALPP
301 PPPPARAFGP GPAETPAVGP GPGPRAALSR SASVRCAGPG GGGGGGAPGA LWTEAREQAL
361 CGPGLRKTKY RSFRRRLLKF IPGLNRSLEE EESQLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TAMALIN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.57
- Highest tissue expression
- 52 nTPM
Expression across tissuesHPA
Tissue
- lung: 52 nTPM
- adipose tissue: 36 nTPM
- breast: 31 nTPM
- heart muscle: 26 nTPM
- cerebral cortex: 25 nTPM
- bone marrow: 23 nTPM
Single-cell type
- tuft cells: 473 nCPM
- cdc: 163 nCPM
- vascular endothelial cells: 163 nCPM
- pdcs: 141 nCPM
- monocytes: 122 nCPM
- innate lymphoid cells: 116 nCPM
Immune cell
- myeloid DC: 0.1 nTPM
- plasmacytoid DC: 0.1 nTPM
- T-reg: 0.1 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
Brain region
- cerebral cortex: 50 nTPM
- basal ganglia: 37 nTPM
- amygdala: 26 nTPM
- thalamus: 22 nTPM
- white matter: 20 nTPM
- hippocampal formation: 20 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.39
- gnomAD pLI
- 0.9
- DepMap mean gene effect
- -0.17
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of TAMALIN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TAMALIN as an antibody target. Whether an autoantibody or antibody against TAMALIN could matter depends on whether native TAMALIN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TAMALIN is annotated at the cell surface, where native TAMALIN is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label TAMALIN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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