Seroatlas · Human Serome Atlas

TMEM102

Transmembrane protein 102

Also known as: CBAP, FLJ36878, TM102_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N9M5
Gene
TMEM102
Ensembl
ENSG00000181284
Chromosome
17
Canonical length
508 aa
Protein class
Predicted intracellular proteins
Subcellular location
Vesicles

OverviewNCBI Gene

Involved in regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; response to cytokine; and signal transduction. Acts upstream of or within positive regulation of T cell migration and positive regulation of cell adhesion. Located in cell surface. Part of protein-containing complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

508 residues, UniProt reviewed canonical sequence.

>Q8N9M5|TMEM102
     1  MASAVWGSAP WWGPPPPAPA RPLTDIDFCS GAQLQELTQL IQELGVQESW SDGPKPGADL
    61  LRAKDFVFSL LGLVHRRDPR FPPQAELLLL RGGIREGSLD LGHAPLGPYA RGPHYDAGFT
   121  LLVPMFSLDG TELQLDLESC YAQVCLPEMV CGTPIREMWQ DCLGPPVPGA RDSIHRTESE
   181  ESSKDWQSSV DQPHSYVTEH EAPVSLEKSP SDVSASESPQ HDVVDLGSTA PLKTMSSDVT
   241  KAAVESPVPK PSEAREAWPT LCSAQVAAWF FATLAAVAES LIPVPGAPRL VHAARHAGFT
   301  TVLLATPEPP RRLLLFDLIP VVSVAGWPEG ARSHSWAGPL ASESASFYLV PGGGTERPCA
   361  SAWQLCFARQ ELALKARIPA PLLQAHAAAQ ALLRPLVAGT RAAAPYLLRT LLYWACERLP
   421  ALYLARPENA GACCLGLLDE LGRVLEAGTL PHYFLNGRQL RTGDDSAALL GELARLRGDP
   481  ARALRAAVEE AKVARKGGGL AGVGGGAH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM102 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
9.8 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 9.8 nTPM
  • skin: 8.5 nTPM
  • adrenal gland: 8.1 nTPM
  • testis: 6.4 nTPM
  • spleen: 6.1 nTPM
  • salivary gland: 5.9 nTPM

Single-cell type

  • paneth cells: 3.9 nCPM
  • papillary tip epithelial cells: 3.3 nCPM
  • renal collecting duct principal cells: 2.4 nCPM
  • loop of henle epithelial cells: 1.7 nCPM
  • late spermatids: 1.5 nCPM
  • podocytes: 1.5 nCPM

Immune cell

  • eosinophil: 3.9 nTPM
  • NK-cell: 1 nTPM
  • non-classical monocyte: 1 nTPM
  • intermediate monocyte: 0.9 nTPM
  • memory CD8 T-cell: 0.9 nTPM
  • memory B-cell: 0.8 nTPM

Brain region

  • cerebellum: 2 nTPM
  • medulla oblongata: 2 nTPM
  • pons: 1.8 nTPM
  • thalamus: 1.8 nTPM
  • basal ganglia: 1.7 nTPM
  • midbrain: 1.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.12
gnomAD pLI
0
gnomAD missense Z
0.92
DepMap mean gene effect
-0.11
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TMEM102 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM102 as an antibody target. Whether an autoantibody or antibody against TMEM102 could matter depends on whether native TMEM102 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM102 is annotated at the cell surface, where native TMEM102 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TMEM102 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TMEM102. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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