Seroatlas · Human Serome Atlas

SCARA3

Scavenger receptor class A member 3

Also known as: APC7, CSR, CSR1, MSLR1, MSRL1, SCAR3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6AZY7
Gene
SCARA3
Ensembl
ENSG00000168077
Chromosome
8
Canonical length
606 aa
Protein class
Predicted membrane proteins
Subcellular location
Endoplasmic reticulum

OverviewNCBI Gene

This gene encodes a macrophage scavenger receptor-like protein. This protein has been shown to deplete reactive oxygen species, and thus play an important role in protecting cells from oxidative stress. The expression of this gene is induced by oxidative stress. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

606 residues, UniProt reviewed canonical sequence.

>Q6AZY7|SCARA3
     1  MKVRSAGGDG DALCVTEEDL AGDDEDMPTF PCTQKGRPGP RCSRCQKNLS LHTSVRILYL
    61  FLALLLVAVA VLASLVFRKV DSLSEDISLT QSIYDKKLVL MQKNLQGLDP KALNNCSFCH
   121  EAGQLGPEIR KLQEELEGIQ KLLLAQEVQL DQTLQAQEVL STTSRQISQE MGSCSFSIHQ
   181  VNQSLGLFLA QVRGWQATTA GLDLSLKDLT QECYDVKAAV HQINFTVGQT SEWIHGIQRK
   241  TDEETLTLQK IVTDWQNYTR LFSGLRTTST KTGEAVKNIQ ATLGASSQRI SQNSESMHDL
   301  VLQVMGLQLQ LDNISSFLDD HEENMHDLQY HTHYAQNRTV ERFESLEGRM ASHEIEIGTI
   361  FTNINATDNH VHSMLKYLDD VRLSCTLGFH THAEELYYLN KSVSIMLGTT DLLRERFSLL
   421  SARLDLNVRN LSMIVEEMKA VDTQHGEILR NVTILRGAPG PPGPRGFKGD MGVKGPVGGR
   481  GPKGDPGSLG PLGPQGPQGQ PGEAGPVGER GPVGPRGFPG LKGSKGSFGT GGPRGQPGPK
   541  GDIGPPGPEG PPGSPGPSGP QGKPGIAGKT GSPGQRGAMG PKGEPGIQGP PGLPGPPGPP
   601  GSQSFY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SCARA3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.58
Highest tissue expression
89 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 89 nTPM
  • fallopian tube: 82 nTPM
  • endometrium: 74 nTPM
  • smooth muscle: 64 nTPM
  • seminal vesicle: 63 nTPM
  • basal ganglia: 62 nTPM

Single-cell type

  • fallopian secretory cells: 168 nCPM
  • medullary thymic epithelial cells: 137 nCPM
  • bergmann glia: 123 nCPM
  • astrocytes: 114 nCPM
  • submucosal glandular cells: 94 nCPM
  • ocular epithelial cells: 82 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • medulla oblongata: 245 nTPM
  • midbrain: 145 nTPM
  • spinal cord: 125 nTPM
  • pons: 123 nTPM
  • thalamus: 121 nTPM
  • white matter: 102 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.05
gnomAD pLI
0
gnomAD missense Z
0.25
DepMap mean gene effect
0.1
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SCARA3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SCARA3 as an antibody target. Whether an autoantibody or antibody against SCARA3 could matter depends on whether native SCARA3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SCARA3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SCARA3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SCARA3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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