Seroatlas · Human Serome Atlas

COG1

Conserved oligomeric Golgi complex subunit 1

Also known as: COG1_HUMAN, KIAA1381, LDLB

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WTW3
Gene: COG1
Ensembl: ENSG00000166685
Chromosome: 17
Canonical length: 980 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene is one of eight proteins (Cog1-8) which form a Golgi-localized complex (COG) required for normal Golgi morphology and function. It is thought that this protein is required for steps in the normal medial and trans Golgi-associated processing of glycoconjugates and plays a role in the organization of the Golgi-localized complex. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

980 residues, UniProt reviewed canonical sequence.

>Q8WTW3|COG1
     1  MATAATSPAL KRLDLRDPAA LFETHGAEEI RGLERQVRAE IEHKKEELRQ MVGERYRDLI
    61  EAADTIGQMR RCAVGLVDAV KATDQYCARL RQAGSAAPRP PRAQQPQQPS QEKFYSMAAQ
   121  IKLLLEIPEK IWSSMEASQC LHATQLYLLC CHLHSLLQLD SSSSRYSPVL SRFPILIRQV
   181  AAASHFRSTI LHESKMLLKC QGVSDQAVAE ALCSIMLLEE SSPRQALTDF LLARKATIQK
   241  LLNQPHHGAG IKAQICSLVE LLATTLKQAH ALFYTLPEGL LPDPALPCGL LFSTLETITG
   301  QHPAGKGTGV LQEEMKLCSW FKHLPASIVE FQPTLRTLAH PISQEYLKDT LQKWIHMCNE
   361  DIKNGITNLL MYVKSMKGLA GIRDAMWELL TNESTNHSWD VLCRRLLEKP LLFWEDMMQQ
   421  LFLDRLQTLT KEGFDSISSS SKELLVSALQ ELESSTSNSP SNKHIHFEYN MSLFLWSESP
   481  NDLPSDAAWV SVANRGQFAS SGLSMKAQAI SPCVQNFCSA LDSKLKVKLD DLLAYLPSDD
   541  SSLPKDVSPT QAKSSAFDRY ADAGTVQEML RTQSVACIKH IVDCIRAELQ SIEEGVQGQQ
   601  DALNSAKLHS VLFMARLCQS LGELCPHLKQ CILGKSESSE KPAREFRALR KQGKVKTQEI
   661  IPTQAKWQEV KEVLLQQSVM GYQVWSSAVV KVLIHGFTQS LLLDDAGSVL ATATSWDELE
   721  IQEEAESGSS VTSKIRLPAQ PSWYVQSFLF SLCQEINRVG GHALPKVTLQ EMLKSCMVQV
   781  VAAYEKLSEE KQIKKEGAFP VTQNRALQLL YDLRYLNIVL TAKGDEVKSG RSKPDSRIEK
   841  VTDHLEALID PFDLDVFTPH LNSNLHRLVQ RTSVLFGLVT GTENQLAPRS STFNSQEPHN
   901  ILPLASSQIR FGLLPLSMTS TRKAKSTRNI ETKAQVVPPA RSTAGDPTVP GSLFRQLVSE
   961  EDNTSAPSLF KLGWLSSMTK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against COG1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 54 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 54 nTPM
basal ganglia: 49 nTPM
heart muscle: 43 nTPM
cerebellum: 42 nTPM
cerebral cortex: 41 nTPM
hippocampal formation: 35 nTPM

Single-cell type

cardiomyocytes: 44 nCPM
adrenal cortex cells: 41 nCPM
brain excitatory neurons: 40 nCPM
somatotrophs: 32 nCPM
brain inhibitory neurons: 32 nCPM
retinal amacrine cells: 31 nCPM

Immune cell

eosinophil: 19 nTPM
naive CD8 T-cell: 19 nTPM
memory CD4 T-cell: 19 nTPM
MAIT T-cell: 18 nTPM
NK-cell: 18 nTPM
memory CD8 T-cell: 17 nTPM

Brain region

cerebral cortex: 67 nTPM
basal ganglia: 60 nTPM
hippocampal formation: 55 nTPM
amygdala: 52 nTPM
hypothalamus: 44 nTPM
white matter: 43 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about COG1.

Disease | AllUniProt

Conditions COG1 is implicated in, by any mechanism.

Congenital disorder of glycosylation 2G (CDG2G) MIM:611209

Disease | GeneticClinVar

24 pathogenic / likely-pathogenic of 570 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

COG1 congenital disorder of glycosylation
Nephrotic syndrome

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.65
gnomAD pLI: 0
gnomAD missense Z: -0.18
DepMap mean gene effect: -0.49
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Vps51/EXO84/COG1 N-terminal
Conserved oligomeric Golgi complex subunit 1

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of COG1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads COG1 as an antibody target. Whether an autoantibody or antibody against COG1 could matter depends on whether native COG1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

COG1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label COG1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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