Seroatlas · Human Serome Atlas

COG3

Conserved oligomeric Golgi complex subunit 3

Also known as: COG3_HUMAN, SEC34

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96JB2
Gene
COG3
Ensembl
ENSG00000136152
Chromosome
13
Canonical length
828 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Golgi apparatus,Plasma membrane,Cytosol

OverviewNCBI Gene

This gene encodes a component of the conserved oligomeric Golgi (COG) complex which is composed of eight different subunits and is required for normal Golgi morphology and localization. Defects in the COG complex result in multiple deficiencies in protein glycosylation. The protein encoded by this gene is involved in ER-Golgi transport.[provided by RefSeq, Jun 2011]

Canonical amino-acid sequenceUniProt

828 residues, UniProt reviewed canonical sequence.

>Q96JB2|COG3
     1  MAEAALLLLP EAAAERDARE KLALWDRRPD TTAPLTDRQT DSVLELKAAA ENLPVPAELP
    61  IEDLCSLTSQ SLPIELTSVV PESTEDILLK GFTSLGMEEE RIETAQQFFS WFAKLQTQMD
   121  QDEGTKYRQM RDYLSGFQEQ CDAILNDVNS ALQHLESLQK QYLFVSNKTG TLHEACEQLL
   181  KEQSELVDLA ENIQQKLSYF NELETINTKL NSPTLSVNSD GFIPMLAKLD DCITYISSHP
   241  NFKDYPIYLL KFKQCLSKAL HLMKTYTVNT LQTLTSQLLK RDPSSVPNAD NAFTLFYVKF
   301  RAAAPKVRTL IEQIELRSEK IPEYQQLLND IHQCYLDQRE LLLGPSIACT VAELTSQNNR
   361  DHCALVRSGC AFMVHVCQDE HQLYNEFFTK PTSKLDELLE KLCVSLYDVF RPLIIHVIHL
   421  ETLSELCGIL KNEVLEDHVQ NNAEQLGAFA AGVKQMLEDV QERLVYRTHI YIQTDITGYK
   481  PAPGDLAYPD KLVMMEQIAQ SLKDEQKKVP SEASFSDVHL EEGESNSLTK SGSTESLNPR
   541  PQTTISPADL HGMWYPTVRR TLVCLSKLYR CIDRAVFQGL SQEALSACIQ SLLGASESIS
   601  KNKTQIDGQL FLIKHLLILR EQIAPFHTEF TIKEISLDLK KTRDAAFKIL NPMTVPRFFR
   661  LNSNNALIEF LLEGTPEIRE HYLDSKKDVD RHLKSACEQF IQQQTKLFVE QLEEFMTKVS
   721  ALKTMASQGG PKYTLSQQPW AQPAKVNDLA ATAYKTIKTK LPVTLRSMSL YLSNKDTEFI
   781  LFKPVRNNIQ QVFQKFHALL KEEFSPEDIQ IIACPSMEQL SLLLLVSK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against COG3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
27 nTPM

Expression across tissuesHPA

Tissue

  • liver: 27 nTPM
  • pancreas: 20 nTPM
  • rectum: 18 nTPM
  • prostate: 18 nTPM
  • salivary gland: 17 nTPM
  • thyroid gland: 16 nTPM

Single-cell type

  • cardiomyocytes: 143 nCPM
  • gonadotrophs: 114 nCPM
  • hepatocytes: 105 nCPM
  • prostatic glandular cells: 99 nCPM
  • epicardial cells: 98 nCPM
  • somatotrophs: 97 nCPM

Immune cell

  • eosinophil: 3.6 nTPM
  • MAIT T-cell: 3.6 nTPM
  • basophil: 3.5 nTPM
  • gdT-cell: 3.4 nTPM
  • plasmacytoid DC: 3.4 nTPM
  • T-reg: 3 nTPM

Brain region

  • choroid plexus: 22 nTPM
  • cerebellum: 21 nTPM
  • white matter: 18 nTPM
  • cerebral cortex: 16 nTPM
  • thalamus: 16 nTPM
  • basal ganglia: 15 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about COG3.

Disease | AllUniProt

Conditions COG3 is implicated in, by any mechanism.

  • Congenital disorder of glycosylation 2BB (CDG2BB) MIM:620546

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.21
gnomAD pLI
1
gnomAD missense Z
1.57
DepMap mean gene effect
-0.94
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Conserved oligomeric Golgi complex, subunit 3
  • Conserved oligomeric Golgi complex subunit 3, N-terminal
  • Conserved oligomeric Golgi complex subunit 3, C-terminal
  • Conserved oligomeric Golgi complex subunit 3, N-terminal
  • Conserved oligomeric Golgi complex subunit 3, C-terminal

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of COG3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads COG3 as an antibody target. Whether an autoantibody or antibody against COG3 could matter depends on whether native COG3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

COG3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label COG3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/COG3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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