Seroatlas · Human Serome Atlas

COG5

Conserved oligomeric Golgi complex subunit 5

Also known as: COG5_HUMAN, GOLTC1, GTC90

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UP83
Gene: COG5
Ensembl: ENSG00000164597
Chromosome: 7
Canonical length: 860 aa
Protein class: Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Golgi apparatus

OverviewNCBI Gene

The protein encoded by this gene is one of eight proteins (Cog1-8) which form a Golgi-localized complex (COG) required for normal Golgi morphology and function. The encoded protein is organized with conserved oligomeric Golgi complex components 6, 7 and 8 into a sub-complex referred to as lobe B. Alternative splicing results in multiple transcript variants. Mutations in this gene result in congenital disorder of glycosylation type 2I.[provided by RefSeq, Jan 2011]

Canonical amino-acid sequenceUniProt

860 residues, UniProt reviewed canonical sequence.

>Q9UP83|COG5
     1  MGWVGGRRRD SASPPGRSRS AADDINPAPA NMEGGGGSVA VAGLGARGSG AAAATVRELL
    61  QDGCYSDFLN EDFDVKTYTS QSIHQAVIAE QLAKLAQGIS QLDRELHLQV VARHEDLLAQ
   121  ATGIESLEGV LQMMQTRIGA LQGAVDRIKA KIVEPYNKIV ARTAQLARLQ VACDLLRRII
   181  RILNLSKRLQ GQLQGGSREI TKAAQSLNEL DYLSQGIDLS GIEVIENDLL FIARARLEVE
   241  NQAKRLLEQG LETQNPTQVG TALQVFYNLG TLKDTITSVV DGYCATLEEN INSALDIKVL
   301  TQPSQSAVRG GPGRSTMPTP GNTAALRASF WTNMEKLMDH IYAVCGQVQH LQKVLAKKRD
   361  PVSHICFIEE IVKDGQPEIF YTFWNSVTQA LSSQFHMATN SSMFLKQAFE GEYPKLLRLY
   421  NDLWKRLQQY SQHIQGNFNA SGTTDLYVDL QHMEDDAQDI FIPKKPDYDP EKALKDSLQP
   481  YEAAYLSKSL SRLFDPINLV FPPGGRNPPS SDELDGIIKT IASELNVAAV DTNLTLAVSK
   541  NVAKTIQLYS VKSEQLLSTQ GDASQVIGPL TEGQRRNVAV VNSLYKLHQS VTKVVSSQSS
   601  FPLAAEQTII SALKAIHALM ENAVQPLLTS VGDAIEAIII TMHQEDFSGS LSSSGKPDVP
   661  CSLYMKELQG FIARVMSDYF KHFECLDFVF DNTEAIAQRA VELFIRHASL IRPLGEGGKM
   721  RLAADFAQME LAVGPFCRRV SDLGKSYRML RSFRPLLFQA SEHVASSPAL GDVIPFSIII
   781  QFLFTRAPAE LKSPFQRAEW SHTRFSQWLD DHPSEKDRLL LIRGALEAYV QSVRSREGKE
   841  FAPVYPIMVQ LLQKAMSALQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against COG5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 21 nTPM

Expression across tissuesHPA

Tissue

salivary gland: 21 nTPM
cervix: 20 nTPM
heart muscle: 19 nTPM
thyroid gland: 19 nTPM
parathyroid gland: 18 nTPM
prostate: 17 nTPM

Single-cell type

renal collecting duct intercalated cells: 346 nCPM
choroid plexus epithelial cells: 326 nCPM
microglia: 316 nCPM
distal convoluted tubule cells: 235 nCPM
renal connecting tubule cells: 233 nCPM
podocytes: 226 nCPM

Immune cell

basophil: 9.5 nTPM
non-classical monocyte: 9.4 nTPM
MAIT T-cell: 8.4 nTPM
intermediate monocyte: 7.8 nTPM
memory CD4 T-cell: 7.7 nTPM
eosinophil: 7.5 nTPM

Brain region

white matter: 27 nTPM
cerebral cortex: 26 nTPM
choroid plexus: 25 nTPM
thalamus: 25 nTPM
hypothalamus: 25 nTPM
midbrain: 24 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about COG5.

Disease | AllUniProt

Conditions COG5 is implicated in, by any mechanism.

Congenital disorder of glycosylation 2I (CDG2I) MIM:613612

Disease | GeneticClinVar

67 pathogenic / likely-pathogenic of 990 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

COG5-congenital disorder of glycosylation
COG5-related disorder
Inborn genetic diseases
Fetal anomalies with a likely genetic cause

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.97
gnomAD pLI: 0
gnomAD missense Z: -0.48
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Conserved oligomeric Golgi complex subunit 5
Conserved oligomeric Golgi complex subunit 5, helical domain
Conserved oligomeric Golgi complex subunit 5, N-terminal
Conserved oligomeric Golgi complex subunit 5, N-terminal
Conserved oligomeric Golgi complex subunit 5, C-terminal

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of COG5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

COG7

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads COG5 as an antibody target. Whether an autoantibody or antibody against COG5 could matter depends on whether native COG5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

COG5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label COG5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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