Intracellular chloride channel
IPR002946
Definition
The chloride intracellular channel (CLIC) family represent a subgroup of the glutathione-S-transferase (GSTs) superfamily. CLIC proteins can exist as both soluble globular proteins and integral membrane proteins with ion channel function PMID:12202911. Membrane insertion seems to be redox-regulated PMID:14613939 and has a strong pH dependence PMID:11978800. CLIC proteins are enigmatic as they do not fit the patterns of other, well-characterised ion channel proteins that show clear and often multiple TM domains PMID:20085760. They share a conserved C-terminal CLIC module, with several members containing additional, unrelated N-terminal domains. CLIC proteins are highly conserved in vertebrates, which usually possess six distinct paralogues (CLIC1-CLIC6) PMID:20085760. They are multifunctional proteins and participate in a wide variety of signaling activities.
6 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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