Seroatlas · Human Serome Atlas

CIAO2A

Cytosolic iron-sulfur assembly component 2A

Also known as: CIA2A, CIA2A_HUMAN, FAM96A, FLJ22875

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H5X1
Gene: CIAO2A
Ensembl: ENSG00000166797
Chromosome: 15
Canonical length: 160 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol
Secretome location: Intracellular and membrane
Quaternary structure: Homodimer

OverviewNCBI Gene

Predicted to enable metal ion binding activity. Involved in protein maturation. Located in cytosol and nucleoplasm. Part of cytosolic [4Fe-4S] assembly targeting complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

160 residues, UniProt reviewed canonical sequence.

>Q9H5X1|CIAO2A
     1  MQRVSGLLSW TLSRVLWLSG LSEPGAARQP RIMEEKALEV YDLIRTIRDP EKPNTLEELE
    61  VVSESCVEVQ EINEEEYLVI IRFTPTVPHC SLATLIGLCL RVKLQRCLPF KHKLEIYISE
   121  GTHSTEEDIN KQINDKERVA AAMENPNLRE IVEQCVLEPD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CIAO2A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 245 nTPM

Expression across tissuesHPA

Tissue

liver: 245 nTPM
skeletal muscle: 118 nTPM
duodenum: 101 nTPM
lymph node: 98 nTPM
tongue: 91 nTPM
small intestine: 82 nTPM

Single-cell type

hepatocytes: 269 nCPM
parietal cells: 248 nCPM
hofbauer cells: 221 nCPM
kupffer cells: 190 nCPM
enteric transient amplifying cells: 150 nCPM
enterocytes: 141 nCPM

Immune cell

plasmacytoid DC: 388 nTPM
memory B-cell: 348 nTPM
naive B-cell: 348 nTPM
total PBMC: 269 nTPM
classical monocyte: 257 nTPM
intermediate monocyte: 255 nTPM

Brain region

choroid plexus: 57 nTPM
white matter: 41 nTPM
thalamus: 32 nTPM
medulla oblongata: 31 nTPM
spinal cord: 30 nTPM
cerebellum: 29 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.46
gnomAD pLI: 0
DepMap mean gene effect: -0.29
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

metal ion binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CIAO2A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CIAO2A as an antibody target. Whether an autoantibody or antibody against CIAO2A could matter depends on whether native CIAO2A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CIAO2A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CIAO2A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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