Seroatlas · Human Serome Atlas

CFAP45

Cilia- and flagella-associated protein 45

Also known as: CCDC19, CFA45_HUMAN, NESG1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UL16
Gene: CFAP45
Ensembl: ENSG00000213085
Chromosome: 1
Canonical length: 551 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Basal body,Cytosol,Mid piece,Principal piece,End piece

OverviewNCBI Gene

Enables AMP binding activity. Involved in establishment of left/right asymmetry and flagellated sperm motility. Located in axonemal microtubule and sperm flagellum. Implicated in visceral heterotaxy 11. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

551 residues, UniProt reviewed canonical sequence.

>Q9UL16|CFAP45
     1  MPLSTAGILS SSSAASNRSR NKARYRTKAV SSEVDESLFG DIKSPAQGQS DSPIVLLRDK
    61  HTLQKTLTAL GLDRKPETIQ LITRDMVREL IVPTEDPSGE SLIISPEEFE RIKWASHVLT
   121  REELEARDQA FKKEKEATMD AVMTRKKIMK QKEMVWNNNK KLSDLEEVAK ERAQNLLQRA
   181  NKLRMEQEEE LKDMSKIILN AKCHAIRDAQ ILEKQQIQKE LDTEEKRLDQ MMEVERQKSI
   241  QRQEELERKR REERIRGRRQ IVEQMEKNQE ERSLLAEQRE QEKEQMLEYM EQLQEEDLKD
   301  MERRQQQKLK MQAEIKRIND ENQKQKAELL AQEKLADQMV MEFTKKKMAR EAEFEAEQER
   361  IRREKEKEIA RLRAMQEKAQ DYQAEQDALR AKRNQEVADR EWRRKEKENA RKKMETEAEL
   421  RKSRLEQVAF KEHALAVQVQ RDRDEFERIL RAQREQIEKE RLEEEKKATG RLQHANELRR
   481  QVRENQQKEV QNRIATFEEG RRLKEEAQKR RERIDEIKRK KLEELRATGL PEKYCIEAER
   541  KANILPATSV N

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CFAP45 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 42 nTPM

Expression across tissuesHPA

Tissue

fallopian tube: 42 nTPM
choroid plexus: 35 nTPM
testis: 27 nTPM
lung: 4.7 nTPM
hippocampal formation: 3.5 nTPM
hypothalamus: 3.4 nTPM

Single-cell type

respiratory ciliated cells: 344 nCPM
fallopian tube ciliated cells: 310 nCPM
early spermatids: 255 nCPM
late primary spermatocytes: 211 nCPM
epididymal efferent duct ciliated cells: 181 nCPM
ependymal cells: 144 nCPM

Immune cell

eosinophil: 3 nTPM
neutrophil: 2.4 nTPM
naive B-cell: 0.3 nTPM
intermediate monocyte: 0.2 nTPM
memory B-cell: 0.2 nTPM
memory CD8 T-cell: 0.2 nTPM

Brain region

choroid plexus: 27 nTPM
medulla oblongata: 18 nTPM
midbrain: 14 nTPM
spinal cord: 12 nTPM
white matter: 8.1 nTPM
pons: 5.3 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CFAP45.

Disease | AllUniProt

Conditions CFAP45 is implicated in, by any mechanism.

Heterotaxy, visceral, 11, autosomal, with male infertility (HTX11) MIM:619608

Disease | GeneticClinVar

5 pathogenic / likely-pathogenic of 131 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Heterotaxy, visceral, 11, autosomal, with male infertility

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1
gnomAD pLI: 0
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

AMP binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Trichohyalin-plectin-homology domain
Trichohyalin-plectin-homology domain
Cilia- and flagella-associated protein 45

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CFAP45 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CFAP45 as an antibody target. Whether an autoantibody or antibody against CFAP45 could matter depends on whether native CFAP45 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CFAP45 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CFAP45 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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