ENKUR
Enkurin
Also known as: C10orf63, CFAP106, ENKUR_HUMAN, enkurin, MGC26778
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8TC29
- Gene
- ENKUR
- Ensembl
- ENSG00000151023
- Chromosome
- 10
- Canonical length
- 256 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Cytosol,Mid piece,Principal piece
OverviewNCBI Gene
This gene encodes a protein that interacts with calmodulin and several transient receptor potential canonical cation channel proteins. The encoded protein may function as an adaptor to localize signal transduction machinery to calcium channels. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]
Canonical amino-acid sequenceUniProt
256 residues, UniProt reviewed canonical sequence.
>Q8TC29|ENKUR
1 MDPTCSSECI YNLIPSDLKE PPQPPRYISI FKATVKDDMQ KAKTAMKTMG PAKVEVPSPK
61 DFLKKHSKEK TLPPKKNFDR NVPKKPAVPL KTDHPVMGIQ SGKNFINTNA ADIIMGVAKK
121 PKPIYVDKRT GDKHDLEPSG LVPKYINKKD YGVTPEYICK RNEEIKKAQE DYDRYIQENL
181 KKAAMKRLSD EEREAVLQGL KKNWEEVHKE FQSLSVFIDS IPKKIRKQRL EEEMKQLEHD
241 IGIIEKHKII YIANNALocalizationUniProt · AlphaFold · HPA
Whether an antibody against ENKUR can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.55
- Highest tissue expression
- 41 nTPM
Expression across tissuesHPA
Tissue
- fallopian tube: 41 nTPM
- choroid plexus: 16 nTPM
- hypothalamus: 11 nTPM
- midbrain: 11 nTPM
- basal ganglia: 11 nTPM
- hippocampal formation: 8.6 nTPM
Single-cell type
- respiratory ciliated cells: 387 nCPM
- fallopian tube ciliated cells: 297 nCPM
- epididymal efferent duct ciliated cells: 184 nCPM
- platelets: 172 nCPM
- ependymal cells: 166 nCPM
- endometrial ciliated cells: 160 nCPM
Immune cell
- total PBMC: 6.2 nTPM
- neutrophil: 2.7 nTPM
- eosinophil: 0.7 nTPM
- plasmacytoid DC: 0.3 nTPM
- classical monocyte: 0.2 nTPM
- basophil: 0.1 nTPM
Brain region
- medulla oblongata: 25 nTPM
- midbrain: 25 nTPM
- choroid plexus: 23 nTPM
- hypothalamus: 21 nTPM
- spinal cord: 19 nTPM
- white matter: 19 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.2
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.02
- DepMap mean gene effect
- 0.08
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of ENKUR in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ENKUR as an antibody target. Whether an autoantibody or antibody against ENKUR could matter depends on whether native ENKUR is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ENKUR is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ENKUR as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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