Seroatlas · Human Serome Atlas

CFAP410

Cilia- and flagella-associated protein 410

Also known as: A2, C21orf2, CF410_HUMAN, LRRC76, YF5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O43822
Gene
CFAP410
Ensembl
ENSG00000160226
Chromosome
21
Canonical length
256 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Golgi apparatus,Primary cilium transition zone,Basal body,Cytosol

OverviewNCBI Gene

Four alternatively spliced transcript variants encoding four different isoforms have been found for this nuclear gene. All isoforms contain leucine-rich repeats. Three of these isoforms are mitochondrial proteins and one of them lacks the target peptide, so is not located in mitochondrion. This gene is down-regulated in Down syndrome (DS) brain, which may represent mitochondrial dysfunction in DS patients. [provided by RefSeq, Sep 2012]

Canonical amino-acid sequenceUniProt

256 residues, UniProt reviewed canonical sequence.

>O43822|CFAP410
     1  MKLTRKMVLT RAKASELHSV RKLNCWGSRL TDISICQEMP SLEVITLSVN SISTLEPVSR
    61  CQRLSELYLR RNRIPSLAEL FYLKGLPRLR VLWLAENPCC GTSPHRYRMT VLRTLPRLQK
   121  LDNQAVTEEE LSRALSEGEE ITAAPEREGT GHGGPKLCCT LSSLSSAAET GRDPLDSEEE
   181  ATSGAQDERG LKPPSRGQFP SLSARDASSS HRGRNVLTAI LLLLRELDAE GLEAVQQTVG
   241  SRLQALRGEE VQEHAE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CFAP410 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
42 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 42 nTPM
  • basal ganglia: 42 nTPM
  • amygdala: 39 nTPM
  • hippocampal formation: 38 nTPM
  • pituitary gland: 33 nTPM
  • hypothalamus: 32 nTPM

Single-cell type

  • late spermatids: 320 nCPM
  • late primary spermatocytes: 93 nCPM
  • early spermatids: 60 nCPM
  • epicardial cells: 43 nCPM
  • fallopian tube ciliated cells: 27 nCPM
  • epididymal efferent duct ciliated cells: 26 nCPM

Immune cell

  • plasmacytoid DC: 31 nTPM
  • NK-cell: 17 nTPM
  • memory B-cell: 17 nTPM
  • memory CD8 T-cell: 13 nTPM
  • intermediate monocyte: 13 nTPM
  • naive B-cell: 12 nTPM

Brain region

  • thalamus: 33 nTPM
  • midbrain: 30 nTPM
  • medulla oblongata: 28 nTPM
  • cerebral cortex: 27 nTPM
  • white matter: 26 nTPM
  • hypothalamus: 24 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CFAP410.

Disease | AllUniProt

Conditions CFAP410 is implicated in, by any mechanism.

  • Retinal dystrophy with or without macular staphyloma (RDMS) MIM:617547
  • Spondylometaphyseal dysplasia, axial (SMDAX) MIM:602271

Disease | GeneticClinVar

47 pathogenic / likely-pathogenic of 443 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.4
gnomAD pLI
0
DepMap mean gene effect
-0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CFAP410 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CFAP410 as an antibody target. Whether an autoantibody or antibody against CFAP410 could matter depends on whether native CFAP410 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CFAP410 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CFAP410 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CFAP410. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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