Seroatlas · Human Serome Atlas

FAM90A1

Protein FAM90A1

Also known as: F90A1_HUMAN, FLJ10408

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86YD7
Gene: FAM90A1
Ensembl: ENSG00000171847
Chromosome: 12
Canonical length: 464 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

FAM90A1 belongs to subfamily I of the primate-specific FAM90A gene family, which originated from multiple duplications and rearrangements (Bosch et al., 2007 [PubMed 17684299]).[supplied by OMIM, Oct 2009]

Canonical amino-acid sequenceUniProt

464 residues, UniProt reviewed canonical sequence.

>Q86YD7|FAM90A1
     1  MMARRDPKPG AKRLVRAQTL QKQRRAPVGP RAPPPDEEDP RLKCKNCEAF GHTARSTRCP
    61  MKCWKAALVP PNFGEKEGKE NLKPWKPQVE ANPGPLNKDK GEKEERPRPQ DPQRKALLHI
   121  FSRKPPEKPL PNQKGSTESS DYLRVASGPM PVHTTSKRPR VDPVLSDRSA TEMSDRGSVL
   181  ASLSPLRKAS LSSSSSLGPK ERQTGAAADI PQTAVRHQGP EPLLVVKPTH SSPAGGCREV
   241  PQAASKTHGL LQAVSPQAQD KRPAVTSQPC PPAATHSLGL GSNLSFGPGA KRSAPAPIQA
   301  CLNFPKKPRL GPFQIPESAI QGGELGAPEN LQPPPAATEL GPRTSPQTGT RTPAQVLSGD
   361  RQPPHSRPCL PTAQACTMSH HPAASHDGAQ PLRVLFRRLE NGRWSSSLLT APSFHSPEKP
   421  GAFLAQSPHV SEKSEGPCVR VPPSVLYEDL QVPSSSEDSD SDLE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM90A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.71
Highest tissue expression: 6.6 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 6.6 nTPM
retina: 4.3 nTPM
thyroid gland: 2.4 nTPM
gallbladder: 2.3 nTPM
skin: 2.2 nTPM
cerebellum: 2.1 nTPM

Single-cell type

early spermatids: 14 nCPM
epididymal principal cells: 6.5 nCPM
late spermatids: 5.4 nCPM
müller glia: 4.9 nCPM
retinal horizontal cells: 4 nCPM
retinal ganglion cells: 3.9 nCPM

Immune cell

myeloid DC: 0.7 nTPM
plasmacytoid DC: 0.4 nTPM
classical monocyte: 0.2 nTPM
basophil: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

cerebral cortex: 76 nTPM
basal ganglia: 74 nTPM
white matter: 69 nTPM
hypothalamus: 66 nTPM
amygdala: 64 nTPM
cerebellum: 64 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.87
gnomAD pLI: 0
gnomAD missense Z: -1.43
DepMap mean gene effect: 0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

InteractionsUniProt · HPA

Protein binding partners of FAM90A1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM90A1 as an antibody target. Whether an autoantibody or antibody against FAM90A1 could matter depends on whether native FAM90A1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM90A1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM90A1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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