ST14

Protein identityUniProt · HPA

UniProt accession

Q9Y5Y6

Gene

ST14

Ensembl

ENSG00000149418

Chromosome

11

Canonical length

855 aa

Protein class

Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted membrane proteins, Transporters

Subcellular location

Nucleoplasm,Vesicles

OverviewNCBI Gene

The protein encoded by this gene is an epithelial-derived, integral membrane serine protease. This protease forms a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine 1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor/scattering factor, and urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for other proteases and latent growth factors. The expression of this protease has been associated with breast, colon, prostate, and ovarian tumors, which implicates its role in cancer invasion, and metastasis. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

855 residues, UniProt reviewed canonical sequence.

>Q9Y5Y6|ST14
     1  MGSDRARKGG GGPKDFGAGL KYNSRHEKVN GLEEGVEFLP VNNVKKVEKH GPGRWVVLAA
    61  VLIGLLLVLL GIGFLVWHLQ YRDVRVQKVF NGYMRITNEN FVDAYENSNS TEFVSLASKV
   121  KDALKLLYSG VPFLGPYHKE SAVTAFSEGS VIAYYWSEFS IPQHLVEEAE RVMAEERVVM
   181  LPPRARSLKS FVVTSVVAFP TDSKTVQRTQ DNSCSFGLHA RGVELMRFTT PGFPDSPYPA
   241  HARCQWALRG DADSVLSLTF RSFDLASCDE RGSDLVTVYN TLSPMEPHAL VQLCGTYPPS
   301  YNLTFHSSQN VLLITLITNT ERRHPGFEAT FFQLPRMSSC GGRLRKAQGT FNSPYYPGHY
   361  PPNIDCTWNI EVPNNQHVKV RFKFFYLLEP GVPAGTCPKD YVEINGEKYC GERSQFVVTS
   421  NSNKITVRFH SDQSYTDTGF LAEYLSYDSS DPCPGQFTCR TGRCIRKELR CDGWADCTDH
   481  SDELNCSCDA GHQFTCKNKF CKPLFWVCDS VNDCGDNSDE QGCSCPAQTF RCSNGKCLSK
   541  SQQCNGKDDC GDGSDEASCP KVNVVTCTKH TYRCLNGLCL SKGNPECDGK EDCSDGSDEK
   601  DCDCGLRSFT RQARVVGGTD ADEGEWPWQV SLHALGQGHI CGASLISPNW LVSAAHCYID
   661  DRGFRYSDPT QWTAFLGLHD QSQRSAPGVQ ERRLKRIISH PFFNDFTFDY DIALLELEKP
   721  AEYSSMVRPI CLPDASHVFP AGKAIWVTGW GHTQYGGTGA LILQKGEIRV INQTTCENLL
   781  PQQITPRMMC VGFLSGGVDS CQGDSGGPLS SVEADGRIFQ AGVVSWGDGC AQRNKPGVYT
   841  RLPLFRDWIK ENTGV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ST14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.3

Highest tissue expression

136 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ST14.

Disease | AllUniProt

Conditions ST14 is implicated in, by any mechanism.

• Ichthyosis, congenital, autosomal recessive 11 (ARCI11) MIM:602400

Disease | GeneticClinVar

15 pathogenic / likely-pathogenic of 307 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Autosomal recessive congenital ichthyosis 11
• Ichthyosis

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.38

gnomAD pLI

0.56

gnomAD missense Z

1.25

DepMap mean gene effect

0.07

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• epithelial cell morphogenesis involved in placental branching
• keratinocyte differentiation
• neural tube closure
• protein catabolic process
• proteolysis

Molecular functions

• serine-type endopeptidase activity
• serine-type peptidase activity

Cellular components

• basolateral plasma membrane
• external side of plasma membrane
• extracellular space
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• SEA domain
• CUB domain
• Serine proteases, trypsin domain
• Low-density lipoprotein (LDL) receptor class A repeat
• Peptidase S1, PA clan
• Serine proteases, trypsin family, histidine active site
• Low-density lipoprotein (LDL) receptor class A, conserved site
• Serine proteases, trypsin family, serine active site
• Spermadhesin, CUB domain superfamily
• LDL receptor-like superfamily
• SEA domain superfamily
• Low-density lipoprotein receptor domain class A
• Trypsin
• CUB domain
• SEA domain
• Peptidase S1A, matripase

KeywordsUniProt

• Disulfide bond
• Glycoprotein
• Hydrolase
• Hypotrichosis
• Ichthyosis
• Membrane
• Protease
• Repeat
• Serine protease
• Signal-anchor
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of ST14 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CDCP1
• NOTCH2