IGFBP7

Protein identityUniProt · HPA

UniProt accession

Q16270

Gene

IGFBP7

Ensembl

ENSG00000163453

Chromosome

4

Canonical length

282 aa

Protein class

Disease related genes, Plasma proteins, Predicted secreted proteins

Subcellular location

Golgi apparatus

Secretome location

Secreted to blood

OverviewNCBI Gene

This gene encodes a member of the insulin-like growth factor (IGF)-binding protein (IGFBP) family. IGFBPs bind IGFs with high affinity, and regulate IGF availability in body fluids and tissues and modulate IGF binding to its receptors. This protein binds IGF-I and IGF-II with relatively low affinity, and belongs to a subfamily of low-affinity IGFBPs. It also stimulates prostacyclin production and cell adhesion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and one variant has been associated with retinal arterial macroaneurysm (PMID:21835307). [provided by RefSeq, Dec 2011]

Canonical amino-acid sequenceUniProt

282 residues, UniProt reviewed canonical sequence.

>Q16270|IGFBP7
     1  MERPSLRALL LGAAGLLLLL LPLSSSSSSD TCGPCEPASC PPLPPLGCLL GETRDACGCC
    61  PMCARGEGEP CGGGGAGRGY CAPGMECVKS RKRRKGKAGA AAGGPGVSGV CVCKSRYPVC
   121  GSDGTTYPSG CQLRAASQRA ESRGEKAITQ VSKGTCEQGP SIVTPPKDIW NVTGAQVYLS
   181  CEVIGIPTPV LIWNKVKRGH YGVQRTELLP GDRDNLAIQT RGGPEKHEVT GWVLVSPLSK
   241  EDAGEYECHA SNSQGQASAS AKITVVDALH EIPVKKGEGA EL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IGFBP7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.41

Highest tissue expression

4,198 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about IGFBP7.

Disease | AllUniProt

Conditions IGFBP7 is implicated in, by any mechanism.

• Retinal arterial macroaneurysm with supravalvular pulmonic stenosis (RAMSVPS) MIM:614224

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 55 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Familial retinal arterial macroaneurysm
• Retinal arterial macroaneurysm with supravascular pulmonic stenosis

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.12

gnomAD pLI

0

gnomAD missense Z

0.31

DepMap mean gene effect

-0.1

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• angiogenesis
• cell adhesion
• cellular response to prostaglandin E stimulus
• embryo implantation
• negative regulation of cell population proliferation
• regulation of cell growth
• regulation of signal transduction
• regulation of steroid biosynthetic process
• response to cortisol
• response to retinoic acid

Molecular functions

• insulin-like growth factor binding
• receptor ligand activity

Cellular components

• endoplasmic reticulum lumen
• extracellular exosome
• extracellular matrix
• extracellular region
• extracellular space

Protein domainsUniProt · Pfam · InterPro

• Insulin-like growth factor-binding protein, IGFBP
• Kazal domain
• Immunoglobulin domain subtype
• Immunoglobulin-like domain
• Growth factor receptor cysteine-rich domain superfamily
• Insulin-like growth factor binding protein-related protein (IGFBP-rP), MAC25
• Immunoglobulin I-set
• Immunoglobulin-like fold
• Kazal domain superfamily
• Immunoglobulin-like domain superfamily
• Insulin-like growth factor binding protein
• Kazal-type serine protease inhibitor domain
• Immunoglobulin I-set domain

KeywordsUniProt

• Cell adhesion
• Disulfide bond
• Glycoprotein
• Growth factor binding
• Immunoglobulin domain
• Phosphoprotein
• RNA editing
• Secreted
• Signal

InteractionsUniProt · HPA

Protein binding partners of IGFBP7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CD93