Seroatlas · Human Serome Atlas

CD48

CD48 antigen

Also known as: BCM1, BLAST, CD48_HUMAN, hCD48, mCD48, SLAMF2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P09326
Gene
CD48
Ensembl
ENSG00000117091
Chromosome
1
Canonical length
243 aa
Protein class
CD markers, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins, Transporters
Subcellular location
Nucleoli fibrillar center,Plasma membrane,Cytosol
Secretome location
Secreted to blood

OverviewNCBI Gene

This gene encodes a member of the CD2 subfamily of immunoglobulin-like receptors which includes SLAM (signaling lymphocyte activation molecules) proteins. The encoded protein is found on the surface of lymphocytes and other immune cells, dendritic cells and endothelial cells, and participates in activation and differentiation pathways in these cells. The encoded protein does not have a transmembrane domain, however, but is held at the cell surface by a GPI anchor via a C-terminal domain which maybe cleaved to yield a soluble form of the receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Canonical amino-acid sequenceUniProt

243 residues, UniProt reviewed canonical sequence.

>P09326|CD48
     1  MCSRGWDSCL ALELLLLPLS LLVTSIQGHL VHMTVVSGSN VTLNISESLP ENYKQLTWFY
    61  TFDQKIVEWD SRKSKYFESK FKGRVRLDPQ SGALYISKVQ KEDNSTYIMR VLKKTGNEQE
   121  WKIKLQVLDP VPKPVIKIEK IEDMDDNCYL KLSCVIPGES VNYTWYGDKR PFPKELQNSV
   181  LETTLMPHNY SRCYTCQVSN SVSSKNGTVC LSPPCTLARS FGVEWIASWL VVTVPTILGL
   241  LLT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CD48 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
266 nTPM

Expression across tissuesHPA

Tissue

  • lymph node: 266 nTPM
  • tonsil: 241 nTPM
  • spleen: 151 nTPM
  • bone marrow: 140 nTPM
  • thymus: 129 nTPM
  • appendix: 109 nTPM

Single-cell type

  • monocytes: 317 nCPM
  • t-cells: 311 nCPM
  • b-cells: 303 nCPM
  • neutrophils: 295 nCPM
  • nk-cells: 217 nCPM
  • cdc: 191 nCPM

Immune cell

  • total PBMC: 603 nTPM
  • non-classical monocyte: 490 nTPM
  • intermediate monocyte: 471 nTPM
  • MAIT T-cell: 336 nTPM
  • myeloid DC: 330 nTPM
  • classical monocyte: 328 nTPM

Brain region

  • white matter: 5.9 nTPM
  • thalamus: 4.4 nTPM
  • cerebral cortex: 4.2 nTPM
  • pons: 3.3 nTPM
  • medulla oblongata: 3 nTPM
  • choroid plexus: 2.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.49
gnomAD pLI
0
gnomAD missense Z
0.04
DepMap mean gene effect
-0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CD48 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CD48 as an antibody target. Whether an autoantibody or antibody against CD48 could matter depends on whether native CD48 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CD48 is annotated at the cell surface, where native CD48 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CD48 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CD48. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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