Cellular Communication Network Factor
IPR050941
Definition
The CCN family is involved in a wide range of cellular processes including proliferation, adhesion, migration, differentiation, survival, and wound healing. Members of the family act as mitoattractants, mediate cell adhesion through heparin and divalent cations, and enhance growth factor-induced DNA synthesis. They play roles in angiogenesis, matrix remodeling, and bone turnover modulation. CCN proteins interact with integrins and other membrane receptors like NOTCH1, influencing stem cell function, myogenic differentiation, and inflammatory responses. They are implicated in tissue regeneration, endothelial cell function, and metabolic regulation in pancreatic beta-cells.
6 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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