ZDHHC22
Palmitoyltransferase ZDHHC22
Also known as: C14orf59, ZDH22_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8N966
- Gene
- ZDHHC22
- Ensembl
- ENSG00000177108
- Chromosome
- 14
- Canonical length
- 263 aa
- Protein class
- Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins
- Subcellular location
- Plasma membrane
OverviewNCBI Gene
Predicted to enable protein-cysteine S-palmitoyltransferase activity. Involved in protein localization to plasma membrane and protein palmitoylation. Located in Golgi apparatus; endoplasmic reticulum; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
263 residues, UniProt reviewed canonical sequence.
>Q8N966|ZDHHC22
1 MLALRLLNVV APAYFLCISL VTFVLQLFLF LPSMREDPAA ARLFSPALLH GALFLFLSAN
61 ALGNYVLVIQ NSPDDLGACQ GASARKTPCP SPSTHFCRVC ARVTLRHDHH CFFTGNCIGS
121 RNMRNFVLFC LYTSLACLYS MVAGVAYISA VLSISFAHPL AFLTLLPTSI SQFFSGAVLG
181 SEMFVILMLY LWFAIGLACA GFCCHQLLLI LRGQTRHQVR KGVAVRARPW RKNLQEVFGK
241 RWLLGLLVPM FNVGSESSKQ QDKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ZDHHC22 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 4
- Mean surface accessibility (rSASA)
- 0.32
- Highest tissue expression
- 35 nTPM
Expression across tissuesHPA
Tissue
- cerebral cortex: 35 nTPM
- hypothalamus: 24 nTPM
- hippocampal formation: 20 nTPM
- amygdala: 16 nTPM
- midbrain: 15 nTPM
- cerebellum: 12 nTPM
Single-cell type
- oligodendrocyte progenitor cells: 42 nCPM
- other brain neurons: 18 nCPM
- retinal bipolar cells: 15 nCPM
- brain excitatory neurons: 13 nCPM
- retinal amacrine cells: 11 nCPM
- brain inhibitory neurons: 9.7 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- thalamus: 177 nTPM
- cerebral cortex: 138 nTPM
- cerebellum: 122 nTPM
- midbrain: 106 nTPM
- basal ganglia: 99 nTPM
- hippocampal formation: 98 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.05
- gnomAD pLI
- 0.05
- gnomAD missense Z
- 1.14
- DepMap mean gene effect
- -0.05
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of ZDHHC22 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ZDHHC22 as an antibody target. Whether an autoantibody or antibody against ZDHHC22 could matter depends on whether native ZDHHC22 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ZDHHC22 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ZDHHC22 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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