Seroatlas · Human Serome Atlas

CCDC42

Coiled-coil domain-containing protein 42

Also known as: CCD42_HUMAN, CCDC42A, FLJ32734

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96M95
Gene: CCDC42
Ensembl: ENSG00000161973
Chromosome: 17
Canonical length: 316 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be involved in spermatid development. Predicted to act upstream of or within acrosome assembly; centrosome cycle; and cilium assembly. Predicted to be located in several cellular components, including microtubule cytoskeleton; sperm head-tail coupling apparatus; and sperm principal piece. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

316 residues, UniProt reviewed canonical sequence.

>Q96M95|CCDC42
     1  MSLGIMEEED LAEYFRLQYG ERLLQMLQKL PNVEGASESP SIWLLEKKKE TEIMHQTMVQ
    61  KKKMFQRRME TLNLRWEELG VKEAQLKAHI QKSEQFIQEN DQKRIRAMKK ANKERELKCQ
   121  HMQELTKRKQ EMVALRLEHQ RLSAKLKDYY IFNKYLEKVV ENSEFEEIHE VIARYKTLVS
   181  MRHDLMQSAQ EGQEKIERAK ARLARYMEEK DDEILQQNNE LARLQMRFDR ARSNVIFWES
   241  RWAHIQNTAA KKTLLLGTIK MATLNLFQIV SKHLKEVTEV ALEDTHKQLD MIQQFIQDRS
   301  DIWAEVKKKE QQRVRI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC42 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 90 nTPM

Expression across tissuesHPA

Tissue

testis: 90 nTPM
blood vessel: 1.4 nTPM
bone marrow: 0.2 nTPM
liver: 0.2 nTPM
lung: 0.2 nTPM
spleen: 0.2 nTPM

Single-cell type

late primary spermatocytes: 624 nCPM
early primary spermatocytes: 54 nCPM
late spermatids: 47 nCPM
early spermatids: 33 nCPM
hematopoietic stem cells: 7.8 nCPM
megakaryocyte-erythroid progenitors: 2.6 nCPM

Immune cell

memory B-cell: 0.3 nTPM
memory CD4 T-cell: 0.3 nTPM
MAIT T-cell: 0.2 nTPM
memory CD8 T-cell: 0.2 nTPM
naive B-cell: 0.2 nTPM
naive CD8 T-cell: 0.1 nTPM

Brain region

cerebral cortex: 0.7 nTPM
white matter: 0.5 nTPM
amygdala: 0.1 nTPM
basal ganglia: 0.1 nTPM
hippocampal formation: 0.1 nTPM
medulla oblongata: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.07
gnomAD pLI: 0
gnomAD missense Z: 0.66
DepMap mean gene effect: 0.14
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCDC42 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC42 as an antibody target. Whether an autoantibody or antibody against CCDC42 could matter depends on whether native CCDC42 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC42 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC42 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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