Seroatlas · Human Serome Atlas

GPRASP2

G-protein coupled receptor-associated sorting protein 2

Also known as: FLJ37327, GASP2, GASP2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96D09
Gene
GPRASP2
Ensembl
ENSG00000158301
Chromosome
X
Canonical length
838 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a member of a family that regulates the activity of G protein-coupled receptors (GPCRs). The encoded protein has been shown to be capable of interacting with several GPCRs, including the M1 muscarinic acetylcholine receptor and the calcitonin receptor. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010]

Canonical amino-acid sequenceUniProt

838 residues, UniProt reviewed canonical sequence.

>Q96D09|GPRASP2
     1  MTGAEIEPSA QAKPEKKAGE EVIAGPEREN DVPLVVRPKV RTQATTGARP KTETKSVPAA
    61  RPKTEAQAMS GARPKTEVQV MGGARPKTEA QGITGARPKT DARAVGGARS KTDAKAIPGA
   121  RPKDEAQAWA QSEFGTEAVS QAEGVSQTNA VAWPLATAES GSVTKSKGLS MDRELVNVDA
   181  ETFPGTQGQK GIQPWFGPGE ETNMGSWCYS RPRAREEASN ESGFWSADET STASSFWTGE
   241  ETSVRSWPRE ESNTRSRHRA KHQTNPRSRP RSKQEAYVDS WSGSEDEASN PFSFWVGENT
   301  NNLFRPRVRE EANIRSKLRT NREDCFESES EDEFYKQSWV LPGEEANSRF RHRDKEDPNT
   361  ALKLRAQKDV DSDRVKQEPR FEEEVIIGSW FWAEKEASLE GGASAICESE PGTEEGAIGG
   421  SAYWAEEKSS LGAVAREEAK PESEEEAIFG SWFWDRDEAC FDLNPCPVYK VSDRFRDAAE
   481  ELNASSRPQT WDEVTVEFKP GLFHGVGFRS TSPFGIPEEA SEMLEAKPKN LELSPEGEEQ
   541  ESLLQPDQPS PEFTFQYDPS YRSVREIREH LRARESAESE SWSCSCIQCE LKIGSEEFEE
   601  FLLLMDKIRD PFIHEISKIA MGMRSASQFT RDFIRDSGVV SLIETLLNYP SSRVRTSFLE
   661  NMIHMAPPYP NLNMIETFIC QVCEETLAHS VDSLEQLTGI RMLRHLTMTI DYHTLIANYM
   721  SGFLSLLTTA NARTKFHVLK MLLNLSENPA VAKKLFSAKA LSIFVGLFNI EETNDNIQIV
   781  IKMFQNISNI IKSGKMSLID DDFSLEPLIS AFREFEELAK QLQAQIDNQN DPEVGQQS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPRASP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.57
Highest tissue expression
29 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 29 nTPM
  • cerebral cortex: 26 nTPM
  • hypothalamus: 21 nTPM
  • endometrium: 18 nTPM
  • thyroid gland: 16 nTPM
  • adrenal gland: 16 nTPM

Single-cell type

  • other brain neurons: 42 nCPM
  • brain inhibitory neurons: 27 nCPM
  • brain excitatory neurons: 21 nCPM
  • oligodendrocyte progenitor cells: 11 nCPM
  • bergmann glia: 5.9 nCPM
  • astrocytes: 5.1 nCPM

Immune cell

  • naive CD4 T-cell: 1.6 nTPM
  • NK-cell: 0.9 nTPM
  • naive CD8 T-cell: 0.6 nTPM
  • plasmacytoid DC: 0.6 nTPM
  • T-reg: 0.5 nTPM
  • memory CD8 T-cell: 0.4 nTPM

Brain region

  • hypothalamus: 74 nTPM
  • cerebral cortex: 48 nTPM
  • basal ganglia: 44 nTPM
  • pons: 37 nTPM
  • midbrain: 35 nTPM
  • hippocampal formation: 34 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GPRASP2.

Disease | AllUniProt

Conditions GPRASP2 is implicated in, by any mechanism.

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 101 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • X-linked external auditory canal atresia-dilated internal auditory canal-facial dysmorphism syndrome

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.27
gnomAD pLI
0.99
gnomAD missense Z
0.71

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GPRASP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPRASP2 as an antibody target. Whether an autoantibody or antibody against GPRASP2 could matter depends on whether native GPRASP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPRASP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GPRASP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GPRASP2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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