Seroatlas · Human Serome Atlas

CBARP

Voltage-dependent calcium channel beta subunit-associated regulatory protein

Also known as: BARP, C19orf26, CBARP_HUMAN, DOS, MGC40084

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N350
Gene
CBARP
Ensembl
ENSG00000099625
Chromosome
19
Canonical length
705 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Predicted to enable transmembrane transporter binding activity. Predicted to be involved in negative regulation of calcium ion-dependent exocytosis and negative regulation of voltage-gated calcium channel activity. Predicted to be located in growth cone and secretory granule. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

705 residues, UniProt reviewed canonical sequence.

>Q8N350|CBARP
     1  MQPTATMATA ATTTTTTTAT VALTTSWDNA TGRPTAEPDP ILDNYVLLVV VMSLFVGGTL
    61  VVLSGVLLLC KRCWDVHQRL NRAMEEAEKT TTTYLDNGTH PAQDPDFRGE DPECQDAETE
   121  RFLSTSSTGR RVSFNEAALF EQSRKTQDKG RRYTLTEGDF HHLKNARLTH LHLPPLKIVT
   181  IHECDSGEAS SATTPHPATS PKATLAIFQP PGKALTGRSV GPSSALPGDP YNSAAGATDF
   241  AEISPSASSD SGEGTSLDAG TRSTKAGGPG AAAGPGEAGP GSGAGTVLQF LTRLRRHASL
   301  DGASPYFKVK KWKLEPSQRA ASLDTRGSPK RHHFQRQRAA SESTEQEEGD APQEDFIQYI
   361  ARAGDAVAFP HPRPFLASPP PALGRLEAAE AAGGASPDSP PERGAGSAGP EQQQPPLEPD
   421  AERDAGPEQA QTSYRDLWSL RASLELHAAA SDHSSSGNDR DSVRSGDSSG SGSGGAAPAF
   481  PPPSPPAPRP KDGEARRLLQ MDSGYASIEG RGAGDDTEPP AAPARPRSPR AWPRRPRRDY
   541  SIDEKTDALF HEFLRHDPHF DDTPAAARHR ARAHPHARKQ WQRGRQHSDP GARAAPALAG
   601  TPAPPAGAAR PARAPLRRGD SVDGPPDGRT LGGAGDDPAI PVIEEEPGGG GCPGSGLCVL
   661  PSGSVLDKLA AGLDERLFPP RLAEPVVATP ALVAAAPTSP DHSPA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CBARP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.7
Highest tissue expression
20 nTPM

Expression across tissuesHPA

Tissue

  • pituitary gland: 20 nTPM
  • basal ganglia: 17 nTPM
  • hippocampal formation: 12 nTPM
  • cerebral cortex: 12 nTPM
  • amygdala: 9.2 nTPM
  • hypothalamus: 7.4 nTPM

Single-cell type

  • late primary spermatocytes: 148 nCPM
  • late spermatids: 132 nCPM
  • lactotrophs: 83 nCPM
  • somatotrophs: 76 nCPM
  • early spermatids: 42 nCPM
  • brain inhibitory neurons: 26 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 49 nTPM
  • hippocampal formation: 43 nTPM
  • basal ganglia: 38 nTPM
  • amygdala: 30 nTPM
  • medulla oblongata: 25 nTPM
  • hypothalamus: 24 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.59
gnomAD pLI
0.35
DepMap mean gene effect
-0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Voltage-dependent calcium channel beta subunit-associated regulatory protein

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CBARP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CBARP as an antibody target. Whether an autoantibody or antibody against CBARP could matter depends on whether native CBARP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CBARP is annotated at the cell surface, where native CBARP is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CBARP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CBARP. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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