Seroatlas · Human Serome Atlas

CIAPIN1

Anamorsin

Also known as: CIAE2, CPIN1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6FI81
Gene
CIAPIN1
Ensembl
ENSG00000005194
Chromosome
16
Canonical length
312 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Mitochondria

OverviewNCBI Gene

CIAPIN1 is a cytokine-induced inhibitor of apoptosis with no relation to apoptosis regulatory molecules of the BCL2 (MIM 151430) or CASP (see MIM 147678) families. Expression of CIAPIN1 is dependent on growth factor stimulation (Shibayama et al., 2004 [PubMed 14970183]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

312 residues, UniProt reviewed canonical sequence.

>Q6FI81|CIAPIN1
     1  MADFGISAGQ FVAVVWDKSS PVEALKGLVD KLQALTGNEG RVSVENIKQL LQSAHKESSF
    61  DIILSGLVPG STTLHSAEIL AEIARILRPG GCLFLKEPVE TAVDNNSKVK TASKLCSALT
   121  LSGLVEVKEL QREPLTPEEV QSVREHLGHE SDNLLFVQIT GKKPNFEVGS SRQLKLSITK
   181  KSSPSVKPAV DPAAAKLWTL SANDMEDDSM DLIDSDELLD PEDLKKPDPA SLRAASCGEG
   241  KKRKACKNCT CGLAEELEKE KSREQMSSQP KSACGNCYLG DAFRCASCPY LGMPAFKPGE
   301  KVLLSDSNLH DA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CIAPIN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
64 nTPM

Expression across tissuesHPA

Tissue

  • testis: 64 nTPM
  • skeletal muscle: 39 nTPM
  • heart muscle: 37 nTPM
  • tongue: 36 nTPM
  • parathyroid gland: 35 nTPM
  • tonsil: 32 nTPM

Single-cell type

  • late primary spermatocytes: 356 nCPM
  • early primary spermatocytes: 155 nCPM
  • oocytes: 143 nCPM
  • syncytiotrophoblasts: 133 nCPM
  • cytotrophoblasts: 118 nCPM
  • migrating cytotrophoblasts: 87 nCPM

Immune cell

  • total PBMC: 155 nTPM
  • naive CD4 T-cell: 129 nTPM
  • naive CD8 T-cell: 116 nTPM
  • myeloid DC: 95 nTPM
  • NK-cell: 91 nTPM
  • classical monocyte: 81 nTPM

Brain region

  • cerebral cortex: 37 nTPM
  • choroid plexus: 37 nTPM
  • thalamus: 34 nTPM
  • medulla oblongata: 32 nTPM
  • pons: 31 nTPM
  • hypothalamus: 31 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.84
gnomAD pLI
0
gnomAD missense Z
1.12
DepMap mean gene effect
-0.85
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CIAPIN1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CIAPIN1 as an antibody target. Whether an autoantibody or antibody against CIAPIN1 could matter depends on whether native CIAPIN1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CIAPIN1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CIAPIN1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CIAPIN1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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