MAPK1IP1L
MAPK-interacting and spindle-stabilizing protein-like
Also known as: C14orf32, MISSL_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8NDC0
- Gene
- MAPK1IP1L
- Ensembl
- ENSG00000168175
- Chromosome
- 14
- Canonical length
- 245 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Cytosol
OverviewNCBI Gene
No narrative summary is available for MAPK1IP1L in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
245 residues, UniProt reviewed canonical sequence.
>Q8NDC0|MAPK1IP1L
1 MSDEFSLADA LPEHSPAKTS AVSNTKPGQP PQGWPGSNPW NNPSAPSSVP SGLPPSATPS
61 TVPFGPAPTG MYPSVPPTGP PPGPPAPFPP SGPSCPPPGG PYPAPTVPGP GPTGPYPTPN
121 MPFPELPRPY GAPTDPAAAG PLGPWGSMSS GPWAPGMGGQ YPTPNMPYPS PGPYPAPPPP
181 QAPGAAPPVP WGTVPPGAWG PPAPYPAPTG SYPTPGLYPT PSNPFQVPSG PSGAPPMPGG
241 PHSYHLocalizationUniProt · AlphaFold · HPA
Whether an antibody against MAPK1IP1L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.7
- Highest tissue expression
- 79 nTPM
Expression across tissuesHPA
Tissue
- bone marrow: 79 nTPM
- kidney: 35 nTPM
- tonsil: 34 nTPM
- smooth muscle: 33 nTPM
- ovary: 33 nTPM
- urinary bladder: 32 nTPM
Single-cell type
- esophageal apical cells: 225 nCPM
- syncytiotrophoblasts: 195 nCPM
- neutrophils: 182 nCPM
- extravillous trophoblasts: 168 nCPM
- cytotrophoblasts: 166 nCPM
- neutrophil progenitors: 157 nCPM
Immune cell
- basophil: 44 nTPM
- T-reg: 38 nTPM
- intermediate monocyte: 37 nTPM
- plasmacytoid DC: 37 nTPM
- non-classical monocyte: 37 nTPM
- eosinophil: 32 nTPM
Brain region
- hypothalamus: 34 nTPM
- cerebral cortex: 33 nTPM
- medulla oblongata: 31 nTPM
- midbrain: 30 nTPM
- pons: 29 nTPM
- thalamus: 29 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.62
- gnomAD pLI
- 0.65
- gnomAD missense Z
- 0.6
- DepMap mean gene effect
- -0.17
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
- MAPK-interacting and spindle-stabilising protein
- MAPK-interacting and spindle-stabilising protein-like
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of MAPK1IP1L in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads MAPK1IP1L as an antibody target. Whether an autoantibody or antibody against MAPK1IP1L could matter depends on whether native MAPK1IP1L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
MAPK1IP1L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label MAPK1IP1L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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