Seroatlas · Human Serome Atlas

USO1

General vesicular transport factor p115

Also known as: p115, TAP, USO1_HUMAN, VDP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O60763
Gene
USO1
Ensembl
ENSG00000138768
Chromosome
4
Canonical length
962 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoli fibrillar center,Golgi apparatus
Quaternary structure
Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a peripheral membrane protein which recycles between the cytosol and the Golgi apparatus during interphase. It is regulated by phosphorylation: dephosphorylated protein associates with the Golgi membrane and dissociates from the membrane upon phosphorylation. Ras-associated protein 1 recruits this protein to coat protein complex II (COPII) vesicles during budding from the endoplasmic reticulum, where it interacts with a set of COPII vesicle-associated SNAREs to form a cis-SNARE complex that promotes targeting to the Golgi apparatus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

Canonical amino-acid sequenceUniProt

962 residues, UniProt reviewed canonical sequence.

>O60763|USO1
     1  MNFLRGVMGG QSAGPQHTEA ETIQKLCDRV ASSTLLDDRR NAVRALKSLS KKYRLEVGIQ
    61  AMEHLIHVLQ TDRSDSEIIG YALDTLYNII SNEEEEEVEE NSTRQSEDLG SQFTEIFIKQ
   121  QENVTLLLSL LEEFDFHVRW PGVKLLTSLL KQLGPQVQQI ILVSPMGVSR LMDLLADSRE
   181  VIRNDGVLLL QALTRSNGAI QKIVAFENAF ERLLDIISEE GNSDGGIVVE DCLILLQNLL
   241  KNNNSNQNFF KEGSYIQRMK PWFEVGDENS GWSAQKVTNL HLMLQLVRVL VSPTNPPGAT
   301  SSCQKAMFQC GLLQQLCTIL MATGVPADIL TETINTVSEV IRGCQVNQDY FASVNAPSNP
   361  PRPAIVVLLM SMVNERQPFV LRCAVLYCFQ CFLYKNQKGQ GEIVSTLLPS TIDATGNSVS
   421  AGQLLCGGLF STDSLSNWCA AVALAHALQE NATQKEQLLR VQLATSIGNP PVSLLQQCTN
   481  ILSQGSKIQT RVGLLMLLCT WLSNCPIAVT HFLHNSANVP FLTGQIAENL GEEEQLVQGL
   541  CALLLGISIY FNDNSLESYM KEKLKQLIEK RIGKENFIEK LGFISKHELY SRASQKPQPN
   601  FPSPEYMIFD HEFTKLVKEL EGVITKAIYK SSEEDKKEEE VKKTLEQHDN IVTHYKNMIR
   661  EQDLQLEELR QQVSTLKCQN EQLQTAVTQQ VSQIQQHKDQ YNLLKIQLGK DNQHQGSYSE
   721  GAQMNGIQPE EIGRLREEIE ELKRNQELLQ SQLTEKDSMI ENMKSSQTSG TNEQSSAIVS
   781  ARDSEQVAEL KQELATLKSQ LNSQSVEITK LQTEKQELLQ KTEAFAKSVE VQGETETIIA
   841  TKTTDVEGRL SALLQETKEL KNEIKALSEE RTAIKEQLDS SNSTIAILQT EKDKLELEIT
   901  DSKKEQDDLL VLLADQDQKI LSLKNKLKDL GHPVEEEDEL ESGDQEDEDD ESEDPGKDLD
   961  HI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against USO1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
208 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 208 nTPM
  • tongue: 130 nTPM
  • liver: 72 nTPM
  • epididymis: 61 nTPM
  • pancreas: 54 nTPM
  • heart muscle: 54 nTPM

Single-cell type

  • myonuclei: 639 nCPM
  • epididymal principal cells: 292 nCPM
  • plasma cells: 263 nCPM
  • esophageal apical cells: 260 nCPM
  • gonadotrophs: 235 nCPM
  • pancreatic acinar cells: 227 nCPM

Immune cell

  • non-classical monocyte: 27 nTPM
  • MAIT T-cell: 22 nTPM
  • NK-cell: 22 nTPM
  • basophil: 22 nTPM
  • intermediate monocyte: 19 nTPM
  • myeloid DC: 17 nTPM

Brain region

  • choroid plexus: 53 nTPM
  • white matter: 38 nTPM
  • medulla oblongata: 34 nTPM
  • pons: 32 nTPM
  • hypothalamus: 32 nTPM
  • thalamus: 32 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.37
gnomAD pLI
0.33
gnomAD missense Z
1.28

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Armadillo
  • Armadillo-like helical
  • Armadillo-type fold
  • Vesicle tethering protein Uso1/P115-like, head domain
  • Uso1/p115-like vesicle tethering protein, C-terminal
  • Vesicle tethering protein p115
  • Vesicle tethering protein p115, armadillo tether-repeat
  • Uso1 / p115 like vesicle tethering protein, head region
  • Uso1 / p115 like vesicle tethering protein, C terminal region
  • Armadillo tether-repeat of vescicular transport factor

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of USO1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads USO1 as an antibody target. Whether an autoantibody or antibody against USO1 could matter depends on whether native USO1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

USO1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label USO1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/USO1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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