Seroatlas · Human Serome Atlas

BZW1

eIF5-mimic protein 2

Also known as: 5MP2, 5MP2_HUMAN, BZAP45, KIAA0005

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7L1Q6
Gene: BZW1
Ensembl: ENSG00000082153
Chromosome: 2
Canonical length: 419 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Enables RNA binding activity and cadherin binding activity. Involved in regulation of translational initiation. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

419 residues, UniProt reviewed canonical sequence.

>Q7L1Q6|BZW1
     1  MNNQKQQKPT LSGQRFKTRK RDEKERFDPT QFQDCIIQGL TETGTDLEAV AKFLDASGAK
    61  LDYRRYAETL FDILVAGGML APGGTLADDM MRTDVCVFAA QEDLETMQAF AQVFNKLIRR
   121  YKYLEKGFED EVKKLLLFLK GFSESERNKL AMLTGVLLAN GTLNASILNS LYNENLVKEG
   181  VSAAFAVKLF KSWINEKDIN AVAASLRKVS MDNRLMELFP ANKQSVEHFT KYFTEAGLKE
   241  LSEYVRNQQT IGARKELQKE LQEQMSRGDP FKDIILYVKE EMKKNNIPEP VVIGIVWSSV
   301  MSTVEWNKKE ELVAEQAIKH LKQYSPLLAA FTTQGQSELT LLLKIQEYCY DNIHFMKAFQ
   361  KIVVLFYKAE VLSEEPILKW YKDAHVAKGK SVFLEQMKKF VEWLKNAEEE SESEAEEGD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BZW1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 212 nTPM

Expression across tissuesHPA

Tissue

liver: 212 nTPM
bone marrow: 207 nTPM
testis: 160 nTPM
urinary bladder: 154 nTPM
adipose tissue: 122 nTPM
adrenal gland: 122 nTPM

Single-cell type

late spermatids: 2,865 nCPM
early spermatids: 548 nCPM
esophageal apical cells: 413 nCPM
ocular epithelial cells: 358 nCPM
urothelial cells: 273 nCPM
megakaryocytes: 272 nCPM

Immune cell

total PBMC: 296 nTPM
basophil: 238 nTPM
NK-cell: 219 nTPM
MAIT T-cell: 208 nTPM
non-classical monocyte: 197 nTPM
gdT-cell: 179 nTPM

Brain region

choroid plexus: 109 nTPM
white matter: 101 nTPM
thalamus: 97 nTPM
cerebral cortex: 92 nTPM
spinal cord: 88 nTPM
cerebellum: 85 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.35
gnomAD pLI: 0.94
gnomAD missense Z: 3.03
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of translational initiation

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BZW1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BZW1 as an antibody target. Whether an autoantibody or antibody against BZW1 could matter depends on whether native BZW1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BZW1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BZW1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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