Seroatlas · Human Serome Atlas

BRI3BP

BRI3-binding protein

Also known as: BNAS1, BRI3B_HUMAN, HCCR-2, HCCRBP-3, KG19

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WY22
Gene: BRI3BP
Ensembl: ENSG00000184992
Chromosome: 12
Canonical length: 251 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Nucleoplasm,Mitochondria

OverviewNCBI Gene

Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

251 residues, UniProt reviewed canonical sequence.

>Q8WY22|BRI3BP
     1  MGARASGGPL ARAGLLLLLL LLLLLGLLAP GAQGARGRGG AEKNSYRRTV NTFSQSVSSL
    61  FGEDNVRAAQ KFLARLTERF VLGVDMFVET LWKVWTELLD VLGLDVSNLS QYFSPASVSS
   121  SPARALLLVG VVLLAYWFLS LTLGFTFSVL HVVFGRFFWI VRVVLFSMSC VYILHKYEGE
   181  PENAVLPLCF VVAVYFMTGP MGFYWRSSPS GPSNPSNPSV EEKLEHLEKQ VRLLNIRLNR
   241  VLESLDRSKD K

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BRI3BP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 3
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

duodenum: 20 nTPM
small intestine: 18 nTPM
tonsil: 15 nTPM
colon: 15 nTPM
rectum: 14 nTPM
lymph node: 13 nTPM

Single-cell type

late spermatids: 313 nCPM
monocyte progenitors: 129 nCPM
enteric transient amplifying cells: 85 nCPM
neutrophil progenitors: 82 nCPM
colonocytes: 73 nCPM
megakaryocyte progenitors: 70 nCPM

Immune cell

eosinophil: 13 nTPM
plasmacytoid DC: 4.2 nTPM
basophil: 4.1 nTPM
classical monocyte: 2.2 nTPM
neutrophil: 2.2 nTPM
myeloid DC: 1.7 nTPM

Brain region

basal ganglia: 28 nTPM
cerebral cortex: 28 nTPM
pons: 27 nTPM
midbrain: 27 nTPM
spinal cord: 26 nTPM
white matter: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.99
gnomAD pLI: 0.06
gnomAD missense Z: 1.2
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

Negative regulator of p53/TP53
BRI3-binding protein

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BRI3BP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BRI3BP as an antibody target. Whether an autoantibody or antibody against BRI3BP could matter depends on whether native BRI3BP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BRI3BP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BRI3BP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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