Seroatlas · Human Serome Atlas

LETMD1

LETM1 domain-containing protein 1

Also known as: HCCR, HCCR-1, HCCR-2, HCCR1, HCCR2, LTMD1_HUMAN, SLC55A3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6P1Q0
Gene
LETMD1
Ensembl
ENSG00000050426
Chromosome
12
Canonical length
360 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Nucleoplasm,Nucleoli,Mitochondria

OverviewNCBI Gene

This gene encodes a mitochondrial outer membrane protein. It has a potential role in tumorigenesis, which may result from negative regulation of the p53 tumor suppressor gene. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

360 residues, UniProt reviewed canonical sequence.

>Q6P1Q0|LETMD1
     1  MALSRVCWAR SAVWGSAVTP GHFVTRRLQL GRSGLAWGAP RSSKLHLSPK ADVKNLMSYV
    61  VTKTKAINGK YHRFLGRHFP RFYVLYTIFM KGLQMLWADA KKARRIKTNM WKHNIKFHQL
   121  PYREMEHLRQ FRQDVTKCLF LGIISIPPFA NYLVFLLMYL FPRQLLIRHF WTPKQQTDFL
   181  DIYHAFRKQS HPEIISYLEK VIPLISDAGL RWRLTDLCTK IQRGTHPAIH DILALRECFS
   241  NHPLGMNQLQ ALHVKALSRA MLLTSYLPPP LLRHRLKTHT TVIHQLDKAL AKLGIGQLTA
   301  QEVKSACYLR GLNSTHIGED RCRTWLGEWL QISCSLKEAE LSLLLHNVVL LSTNYLGTRR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LETMD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
42 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 42 nTPM
  • liver: 38 nTPM
  • pancreas: 35 nTPM
  • thyroid gland: 35 nTPM
  • duodenum: 34 nTPM
  • ovary: 31 nTPM

Single-cell type

  • parietal cells: 117 nCPM
  • enterocytes: 96 nCPM
  • decidual stromal cells: 91 nCPM
  • distal convoluted tubule cells: 89 nCPM
  • choroid plexus epithelial cells: 88 nCPM
  • enteric stem cells: 85 nCPM

Immune cell

  • naive CD4 T-cell: 21 nTPM
  • naive CD8 T-cell: 19 nTPM
  • T-reg: 17 nTPM
  • memory CD4 T-cell: 17 nTPM
  • non-classical monocyte: 16 nTPM
  • MAIT T-cell: 15 nTPM

Brain region

  • choroid plexus: 29 nTPM
  • pons: 23 nTPM
  • cerebral cortex: 23 nTPM
  • white matter: 22 nTPM
  • basal ganglia: 21 nTPM
  • hypothalamus: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.59
gnomAD pLI
0.05
gnomAD missense Z
0.54
DepMap mean gene effect
-0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LETMD1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LETMD1 as an antibody target. Whether an autoantibody or antibody against LETMD1 could matter depends on whether native LETMD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LETMD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LETMD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LETMD1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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