Seroatlas · Human Serome Atlas

TMEM238L

Transmembrane protein 238-like

Also known as: FORCP, LINC00675, T238L_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A6NJY4
Gene
TMEM238L
Ensembl
ENSG00000263429
Chromosome
17
Canonical length
79 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

Involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress. Located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

79 residues, UniProt reviewed canonical sequence.

>A6NJY4|TMEM238L
     1  MLLGSLWGRC HPGRCALFLI LALLLDAVGL VLLLLGILAP LSSWDFFIYT GALILALSLL
    61  LWIIWYSLNI EVSPEKLDL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM238L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
2
Mean surface accessibility (rSASA)
0.45
Highest tissue expression
43 nTPM

Expression across tissuesHPA

Tissue

  • stomach: 43 nTPM
  • rectum: 35 nTPM
  • colon: 35 nTPM
  • urinary bladder: 20 nTPM
  • duodenum: 17 nTPM
  • small intestine: 16 nTPM

Single-cell type

  • renal collecting duct principal cells: 21 nCPM
  • papillary tip epithelial cells: 20 nCPM
  • renal connecting tubule cells: 3.4 nCPM
  • renal collecting duct intercalated cells: 3.3 nCPM
  • astrocytes: 1.7 nCPM
  • loop of henle epithelial cells: 1.1 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • thalamus: 1.9 nTPM
  • basal ganglia: 1.1 nTPM
  • medulla oblongata: 1.1 nTPM
  • midbrain: 1.1 nTPM
  • amygdala: 1 nTPM
  • hypothalamus: 1 nTPM

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TMEM238L in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM238L as an antibody target. Whether an autoantibody or antibody against TMEM238L could matter depends on whether native TMEM238L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM238L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM238L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TMEM238L. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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