Seroatlas · Human Serome Atlas

ZNF410

Zinc finger protein 410

Also known as: APA-1, APA1, ZN410_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86VK4
Gene: ZNF410
Ensembl: ENSG00000119725
Chromosome: 14
Canonical length: 478 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Enables DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of gene expression and positive regulation of transcription by RNA polymerase II. Predicted to be located in chromosome. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

478 residues, UniProt reviewed canonical sequence.

>Q86VK4|ZNF410
     1  MLSDELESKP ELLVQFVQNT SIPLGQGLVE SEAKDITCLS LLPVTEASEC SRLMLPDDTT
    61  NHSNSSKEVP SSAVLRSLRV NVGPDGEETR AQTVQKSPEF LSTSESSSLL QDLQPSDSTS
   121  FILLNLTRAG LGSSAEHLVF VQDEAEDSGN DFLSSESTDS SIPWFLRVQE LAHDSLIAAT
   181  RAQLAKNAKT SSNGENVHLG SGDGQSKDSG PLPQVEKKLK CTVEGCDRTF VWPAHFKYHL
   241  KTHRNDRSFI CPAEGCGKSF YVLQRLKVHM RTHNGEKPFM CHESGCGKQF TTAGNLKNHR
   301  RIHTGEKPFL CEAQGCGRSF AEYSSLRKHL VVHSGEKPHQ CQVCGKTFSQ SGSRNVHMRK
   361  HHLQLGAAGS QEQEQTAEPL MGSSLLEEAS VPSKNLVSMN SQPSLGGESL NLPNTNSILG
   421  VDDEVLAEGS PRSLSSVPDV THHLVTMQSG RQSYEVSVLT AVNPQELLNQ GDLTERRT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF410 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 54 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 54 nTPM
testis: 42 nTPM
epididymis: 41 nTPM
ovary: 37 nTPM
skin: 36 nTPM
blood vessel: 33 nTPM

Single-cell type

choroid plexus epithelial cells: 48 nCPM
ependymal cells: 45 nCPM
astrocytes: 38 nCPM
bergmann glia: 36 nCPM
oligodendrocytes: 35 nCPM
microglia: 34 nCPM

Immune cell

eosinophil: 75 nTPM
basophil: 66 nTPM
NK-cell: 61 nTPM
total PBMC: 54 nTPM
MAIT T-cell: 52 nTPM
non-classical monocyte: 51 nTPM

Brain region

white matter: 53 nTPM
cerebellum: 42 nTPM
basal ganglia: 42 nTPM
medulla oblongata: 41 nTPM
choroid plexus: 40 nTPM
pons: 38 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.45
gnomAD pLI: 0.35
gnomAD missense Z: 2.36
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF410 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

BLZF1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF410 as an antibody target. Whether an autoantibody or antibody against ZNF410 could matter depends on whether native ZNF410 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF410 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF410 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...