Seroatlas · Human Serome Atlas

ASCC2

Activating signal cointegrator 1 complex subunit 2

Also known as: ASC1p100, ASCC2_HUMAN, DKFZp586O0223, FLJ21588

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H1I8
Gene: ASCC2
Ensembl: ENSG00000100325
Chromosome: 22
Canonical length: 757 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Focal adhesion sites,Cytosol

OverviewNCBI Gene

Enables K63-linked polyubiquitin modification-dependent protein binding activity. Involved in regulation of DNA-templated transcription; rescue of stalled ribosome; and ribosome-associated ubiquitin-dependent protein catabolic process. Located in nucleus. Part of DNA repair complex and RQC-trigger complex. Is active in cytosolic ribosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

757 residues, UniProt reviewed canonical sequence.

>Q9H1I8|ASCC2
     1  MPALPLDQLQ ITHKDPKTGK LRTSPALHPE QKADRYFVLY KPPPKDNIPA LVEEYLERAT
    61  FVANDLDWLL ALPHDKFWCQ VIFDETLQKC LDSYLRYVPR KFDEGVASAP EVVDMQKRLH
   121  RSVFLTFLRM STHKESKDHF ISPSAFGEIL YNNFLFDIPK ILDLCVLFGK GNSPLLQKMI
   181  GNIFTQQPSY YSDLDETLPT ILQVFSNILQ HCGLQGDGAN TTPQKLEERG RLTPSDMPLL
   241  ELKDIVLYLC DTCTTLWAFL DIFPLACQTF QKHDFCYRLA SFYEAAIPEM ESAIKKRRLE
   301  DSKLLGDLWQ RLSHSRKKLM EIFHIILNQI CLLPILESSC DNIQGFIEEF LQIFSSLLQE
   361  KRFLRDYDAL FPVAEDISLL QQASSVLDET RTAYILQAVE SAWEGVDRRK ATDAKDPSVI
   421  EEPNGEPNGV TVTAEAVSQA SSHPENSEEE ECMGAAAAVG PAMCGVELDS LISQVKDLLP
   481  DLGEGFILAC LEYYHYDPEQ VINNILEERL APTLSQLDRN LDREMKPDPT PLLTSRHNVF
   541  QNDEFDVFSR DSVDLSRVHK GKSTRKEENT RSLLNDKRAV AAQRQRYEQY SVVVEEVPLQ
   601  PGESLPYHSV YYEDEYDDTY DGNQVGANDA DSDDELISRR PFTIPQVLRT KVPREGQEED
   661  DDDEEDDADE EAPKPDHFVQ DPAVLREKAE ARRMAFLAKK GYRHDSSTAV AGSPRGHGQS
   721  RETTQERRKK EANKATRANH NRRTMADRKR SKGMIPS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ASCC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 51 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 51 nTPM
skeletal muscle: 41 nTPM
esophagus: 39 nTPM
stomach: 35 nTPM
liver: 34 nTPM
tonsil: 32 nTPM

Single-cell type

esophageal apical cells: 660 nCPM
late spermatids: 200 nCPM
foveolar cells: 156 nCPM
breast lactating cells: 132 nCPM
extravillous trophoblasts: 118 nCPM
early spermatids: 117 nCPM

Immune cell

eosinophil: 54 nTPM
intermediate monocyte: 49 nTPM
basophil: 45 nTPM
non-classical monocyte: 44 nTPM
myeloid DC: 38 nTPM
NK-cell: 34 nTPM

Brain region

choroid plexus: 24 nTPM
medulla oblongata: 17 nTPM
pons: 17 nTPM
white matter: 16 nTPM
spinal cord: 16 nTPM
midbrain: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.45
gnomAD pLI: 0.03
gnomAD missense Z: 1.21
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Ubiquitin system component CUE
UBA-like superfamily
CUE domain
Activating signal cointegrator 1 complex subunit 2, CUE domain
Activating signal cointegrator 1 complex subunit 2

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ASCC2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ASCC2 as an antibody target. Whether an autoantibody or antibody against ASCC2 could matter depends on whether native ASCC2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ASCC2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ASCC2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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