Seroatlas · Human Serome Atlas

CSRP1

Cysteine and glycine-rich protein 1

Also known as: CSRP, CSRP1_HUMAN, CYRP, D1S181E

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P21291
Gene: CSRP1
Ensembl: ENSG00000159176
Chromosome: 1
Canonical length: 193 aa
Protein class: Plasma proteins, Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a member of the cysteine-rich protein (CSRP) family. This gene family includes a group of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. The LIM/double zinc-finger motif found in this gene product occurs in proteins with critical functions in gene regulation, cell growth, and somatic differentiation. Alternatively spliced transcript variants have been described. [provided by RefSeq, Aug 2010]

Canonical amino-acid sequenceUniProt

193 residues, UniProt reviewed canonical sequence.

>P21291|CSRP1
     1  MPNWGGGKKC GVCQKTVYFA EEVQCEGNSF HKSCFLCMVC KKNLDSTTVA VHGEEIYCKS
    61  CYGKKYGPKG YGYGQGAGTL STDKGESLGI KHEEAPGHRP TTNPNASKFA QKIGGSERCP
   121  RCSQAVYAAE KVIGAGKSWH KACFRCAKCG KGLESTTLAD KDGEIYCKGC YAKNFGPKGF
   181  GFGQGAGALV HSE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CSRP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 2,839 nTPM

Expression across tissuesHPA

Tissue

colon: 2,839 nTPM
blood vessel: 2,631 nTPM
seminal vesicle: 2,421 nTPM
smooth muscle: 1,877 nTPM
urinary bladder: 1,847 nTPM
endometrium: 1,825 nTPM

Single-cell type

smooth muscle cells: 2,898 nCPM
breast myoepithelial cells: 2,138 nCPM
vascular smooth muscle cells: 884 nCPM
megakaryocytes: 544 nCPM
extravillous trophoblasts: 514 nCPM
decidual stromal cells: 453 nCPM

Immune cell

basophil: 76 nTPM
eosinophil: 66 nTPM
myeloid DC: 65 nTPM
non-classical monocyte: 54 nTPM
T-reg: 54 nTPM
classical monocyte: 50 nTPM

Brain region

basal ganglia: 939 nTPM
thalamus: 922 nTPM
medulla oblongata: 895 nTPM
midbrain: 873 nTPM
white matter: 704 nTPM
cerebellum: 679 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.14
gnomAD pLI: 0
gnomAD missense Z: 0.21
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CSRP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CSRP1 as an antibody target. Whether an autoantibody or antibody against CSRP1 could matter depends on whether native CSRP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CSRP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CSRP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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