Seroatlas · Human Serome Atlas

HMBOX1

Homeobox-containing protein 1

Also known as: FLJ21616, HMBX1_HUMAN, HNF1LA, HOT1, PBHNF

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6NT76
Gene
HMBOX1
Ensembl
ENSG00000147421
Chromosome
8
Canonical length
420 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm,Nuclear bodies,Cytosol

OverviewNCBI Gene

Enables double-stranded telomeric DNA binding activity; identical protein binding activity; and sequence-specific double-stranded DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II; telomere maintenance via telomerase; and telomere-telomerase complex assembly. Located in several cellular components, including centrosome; chromosome, telomeric region; and nuclear body. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

420 residues, UniProt reviewed canonical sequence.

>Q6NT76|HMBOX1
     1  MLSSFPVVLL ETMSHYTDEP RFTIEQIDLL QRLRRTGMTK HEILHALETL DRLDQEHSDK
    61  FGRRSSYGGS SYGNSTNNVP ASSSTATAST QTQHSGMSPS PSNSYDTSPQ PCTTNQNGRE
   121  NNERLSTSNG KMSPTRYHAN SMGQRSYSFE ASEEDLDVDD KVEELMRRDS SVIKEEIKAF
   181  LANRRISQAV VAQVTGISQS RISHWLLQQG SDLSEQKKRA FYRWYQLEKT NPGATLSMRP
   241  APIPIEDPEW RQTPPPVSAT SGTFRLRRGS RFTWRKECLA VMESYFNENQ YPDEAKREEI
   301  ANACNAVIQK PGKKLSDLER VTSLKVYNWF ANRRKEIKRR ANIEAAILES HGIDVQSPGG
   361  HSNSDDVDGN DYSEQDDSTS HSDHQDPISL AVEMAAVNHT ILALARQGAN EIKTEALDDD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HMBOX1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.53
Highest tissue expression
10 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 10 nTPM
  • testis: 7.1 nTPM
  • adrenal gland: 6.4 nTPM
  • placenta: 6.3 nTPM
  • thyroid gland: 5.8 nTPM
  • retina: 5.7 nTPM

Single-cell type

  • adrenal cortex cells: 456 nCPM
  • renal collecting duct intercalated cells: 420 nCPM
  • pituicytes/fscs: 387 nCPM
  • lymphatic endothelial cells: 262 nCPM
  • vascular endothelial cells: 248 nCPM
  • thyrotrophs: 216 nCPM

Immune cell

  • non-classical monocyte: 4.8 nTPM
  • memory B-cell: 3.4 nTPM
  • basophil: 3.2 nTPM
  • MAIT T-cell: 2.7 nTPM
  • naive B-cell: 2.7 nTPM
  • intermediate monocyte: 2.6 nTPM

Brain region

  • midbrain: 86 nTPM
  • hypothalamus: 81 nTPM
  • pons: 75 nTPM
  • medulla oblongata: 74 nTPM
  • white matter: 67 nTPM
  • thalamus: 67 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.23
gnomAD pLI
1
gnomAD missense Z
2.46
DepMap mean gene effect
0.14
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HMBOX1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HMBOX1 as an antibody target. Whether an autoantibody or antibody against HMBOX1 could matter depends on whether native HMBOX1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HMBOX1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HMBOX1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/HMBOX1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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