ADRB3

Protein identityUniProt · HPA

UniProt accession

P13945

Gene

ADRB3

Ensembl

ENSG00000188778

Chromosome

8

Canonical length

408 aa

Protein class

FDA approved drug targets, G-protein coupled receptors, Human disease related genes, Predicted membrane proteins

Subcellular location

Basal body

OverviewNCBI Gene

The protein encoded by this gene belongs to the family of beta adrenergic receptors, which mediate catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor is located mainly in the adipose tissue and is involved in the regulation of lipolysis and thermogenesis. Obesity and bodyweight-related disorders are correlated with certain polymorphisms in three subtypes of beta-adrenoceptor, among them, the ADRB3 gene.[provided by RefSeq, Oct 2019]

Canonical amino-acid sequenceUniProt

408 residues, UniProt reviewed canonical sequence.

>P13945|ADRB3
     1  MAPWPHENSS LAPWPDLPTL APNTANTSGL PGVPWEAALA GALLALAVLA TVGGNLLVIV
    61  AIAWTPRLQT MTNVFVTSLA AADLVMGLLV VPPAATLALT GHWPLGATGC ELWTSVDVLC
   121  VTASIETLCA LAVDRYLAVT NPLRYGALVT KRCARTAVVL VWVVSAAVSF APIMSQWWRV
   181  GADAEAQRCH SNPRCCAFAS NMPYVLLSSS VSFYLPLLVM LFVYARVFVV ATRQLRLLRG
   241  ELGRFPPEES PPAPSRSLAP APVGTCAPPE GVPACGRRPA RLLPLREHRA LCTLGLIMGT
   301  FTLCWLPFFL ANVLRALGGP SLVPGPAFLA LNWLGYANSA FNPLIYCRSP DFRSAFRRLL
   361  CRCGRRLPPE PCAAARPALF PSGVPAARSS PAQPRLCQRL DGASWGVS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ADRB3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

7

Mean surface accessibility (rSASA)

0.4

Highest tissue expression

13 nTPM

Expression across tissuesHPA

ReferencesPubMed · IEDB

Publications for ADRB3 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.68

gnomAD pLI

0

gnomAD missense Z

0.41

DepMap mean gene effect

0.01

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• adenylate cyclase-activating adrenergic receptor signaling pathway
• adenylate cyclase-inhibiting adrenergic receptor signaling pathway
• adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
• adenylate cyclase-modulating G protein-coupled receptor signaling pathway
• brown fat cell differentiation
• carbohydrate metabolic process
• diet induced thermogenesis
• eating behavior
• energy reserve metabolic process
• G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
• generation of precursor metabolites and energy
• heat generation
• negative regulation of cardiac muscle contraction
• negative regulation of multicellular organism growth
• negative regulation of smooth muscle contraction
• norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure
• positive regulation of cold-induced thermogenesis
• positive regulation of ERK1 and ERK2 cascade
• positive regulation of lipid catabolic process
• positive regulation of MAPK cascade
• response to cold

Molecular functions

• beta-3 adrenergic receptor binding
• beta-adrenergic receptor activity
• epinephrine binding
• G protein activity
• norepinephrine binding
• protein homodimerization activity
• beta3-adrenergic receptor activity

Cellular components

• plasma membrane
• receptor complex

Protein domainsUniProt · Pfam · InterPro

• G protein-coupled receptor, rhodopsin-like
• Adrenoceptor family
• GPCR, rhodopsin-like, 7TM
• 7 transmembrane receptor (rhodopsin family)
• Beta 3 adrenoceptor

KeywordsUniProt

• Cell membrane
• Diabetes mellitus
• Disulfide bond
• G-protein coupled receptor
• Glycoprotein
• Lipoprotein
• Membrane
• Obesity
• Palmitate
• Receptor
• Transducer
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of ADRB3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ARRDC3