Seroatlas · Human Serome Atlas

SLC1A6

Excitatory amino acid transporter 4

Also known as: EAA4_HUMAN, EAAT4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P48664
Gene
SLC1A6
Ensembl
ENSG00000105143
Chromosome
19
Canonical length
564 aa
Protein class
Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Plasma membrane,Intermediate filaments
Quaternary structure
Homotrimer

OverviewNCBI Gene

Enables L-aspartate transmembrane transporter activity; L-glutamate transmembrane transporter activity; and glutamate:sodium symporter activity. Involved in L-aspartate import across plasma membrane; L-glutamate import across plasma membrane; and neurotransmitter uptake. Located in intermediate filament cytoskeleton and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

564 residues, UniProt reviewed canonical sequence.

>P48664|SLC1A6
     1  MSSHGNSLFL RESGQRLGRV GWLQRLQESL QQRALRTRLR LQTMTLEHVL RFLRRNAFIL
    61  LTVSAVVIGV SLAFALRPYQ LTYRQIKYFS FPGELLMRML QMLVLPLIVS SLVTGMASLD
   121  NKATGRMGMR AAVYYMVTTI IAVFIGILMV TIIHPGKGSK EGLHREGRIE TIPTADAFMD
   181  LIRNMFPPNL VEACFKQFKT QYSTRVVTRT MVRTENGSEP GASMPPPFSV ENGTSFLENV
   241  TRALGTLQEM LSFEETVPVP GSANGINALG LVVFSVAFGL VIGGMKHKGR VLRDFFDSLN
   301  EAIMRLVGII IWYAPVGILF LIAGKILEME DMAVLGGQLG MYTLTVIVGL FLHAGIVLPL
   361  IYFLVTHRNP FPFIGGMLQA LITAMGTSSS SATLPITFRC LEEGLGVDRR ITRFVLPVGA
   421  TVNMDGTALY EALAAIFIAQ VNNYELNLGQ ITTISITATA ASVGAAGIPQ AGLVTMVIVL
   481  TSVGLPTEDI TLIIAVDWFL DRLRTMTNVL GDSIGAAVIE HLSQRELELQ EAELTLPSLG
   541  KPYKSLMAQE KGASRGRGGN ESAM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC1A6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
8
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
105 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 105 nTPM
  • testis: 25 nTPM
  • basal ganglia: 21 nTPM
  • hippocampal formation: 12 nTPM
  • cerebral cortex: 11 nTPM
  • hypothalamus: 8.7 nTPM

Single-cell type

  • late spermatids: 116 nCPM
  • syncytiotrophoblasts: 58 nCPM
  • early spermatids: 53 nCPM
  • late primary spermatocytes: 48 nCPM
  • sertoli cells: 42 nCPM
  • retinal horizontal cells: 24 nCPM

Immune cell

  • basophil: 0.3 nTPM
  • neutrophil: 0.3 nTPM
  • naive B-cell: 0.2 nTPM
  • classical monocyte: 0.1 nTPM
  • eosinophil: 0.1 nTPM
  • memory B-cell: 0.1 nTPM

Brain region

  • cerebellum: 159 nTPM
  • hippocampal formation: 30 nTPM
  • cerebral cortex: 30 nTPM
  • basal ganglia: 25 nTPM
  • pons: 21 nTPM
  • amygdala: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.43
gnomAD pLI
0.76
gnomAD missense Z
2.67
DepMap mean gene effect
0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLC1A6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC1A6 as an antibody target. Whether an autoantibody or antibody against SLC1A6 could matter depends on whether native SLC1A6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC1A6 is annotated at the cell surface, where native SLC1A6 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC1A6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC1A6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...