Amyloid-beta A4 Precursor Protein-Binding
IPR051230
Definition
The Amyloid-beta A4 precursor protein-binding family is involved in synaptic vesicle exocytosis and modulation of amyloid-beta precursor protein (APP) processing, potentially affecting APP-beta formation. Members of the family interact with essential components of the synaptic vesicle exocytotic machinery, such as STXBP1 and Munc18-1. They contain a phosphotyrosine-binding domain (PID/PTB) for binding the cytoplasmic domain of APP and PDZ domains for membrane attachment. Some members also participate in vesicular trafficking and may influence the activity of transcription factors and receptors, contributing to processes like cell migration, proliferation, and cell cycle progression in various cell types. The family includes proteins that may enhance HIF1A activity in macrophages and are involved in exosome biogenesis and tumorigenesis.
5 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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