Seroatlas · Human Serome Atlas

RECK

Reversion-inducing cysteine-rich protein with Kazal motifs

Also known as: hRECK, RECK_HUMAN, ST15

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O95980
Gene: RECK
Ensembl: ENSG00000122707
Chromosome: 9
Canonical length: 971 aa
Protein class: Plasma proteins, Predicted membrane proteins
Subcellular location: Plasma membrane

OverviewNCBI Gene

The protein encoded by this gene is a cysteine-rich, extracellular protein with protease inhibitor-like domains whose expression is suppressed strongly in many tumors and cells transformed by various kinds of oncogenes. In normal cells, this membrane-anchored glycoprotein may serve as a negative regulator for matrix metalloproteinase-9, a key enzyme involved in tumor invasion and metastasis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

Canonical amino-acid sequenceUniProt

971 residues, UniProt reviewed canonical sequence.

>O95980|RECK
     1  MATVRASLRG ALLLLLAVAG VAEVAGGLAP GSAGALCCNH SKDNQMCRDV CEQIFSSKSE
    61  SRLKHLLQRA PDYCPETMVE IWNCMNSSLP GVFKKSDGWV GLGCCELAIA LECRQACKQA
   121  SSKNDISKVC RKEYENALFS CISRNEMGSV CCSYAGHHTN CREYCQAIFR TDSSPGPSQI
   181  KAVENYCASI SPQLIHCVNN YTQSYPMRNP TDSLYCCDRA EDHACQNACK RILMSKKTEM
   241  EIVDGLIEGC KTQPLPQDPL WQCFLESSQS VHPGVTVHPP PSTGLDGAKL HCCSKANTST
   301  CRELCTKLYS MSWGNTQSWQ EFDRFCEYNP VEVSMLTCLA DVREPCQLGC RNLTYCTNFN
   361  NRPTELFRSC NAQSDQGAMN DMKLWEKGSI KMPFINIPVL DIKKCQPEMW KAIACSLQIK
   421  PCHSKSRGSI ICKSDCVEIL KKCGDQNKFP EDHTAESICE LLSPTDDLKN CIPLDTYLRP
   481  STLGNIVEEV THPCNPNPCP ANELCEVNRK GCPSGDPCLP YFCVQGCKLG EASDFIVRQG
   541  TLIQVPSSAG EVGCYKICSC GQSGLLENCM EMHCIDLQKS CIVGGKRKSH GTSFSIDCNV
   601  CSCFAGNLVC STRLCLSEHS SEDDRRTFTG LPCNCADQFV PVCGQNGRTY PSACIARCVG
   661  LQDHQFEFGS CMSKDPCNPN PCQKNQRCIP KPQVCLTTFD KFGCSQYECV PRQLACDQVQ
   721  DPVCDTDHME HNNLCTLYQR GKSLSYKGPC QPFCRATEPV CGHNGETYSS VCAAYSDRVA
   781  VDYYGDCQAV GVLSEHSSVA ECASVKCPSL LAAGCKPIIP PGACCPLCAG MLRVLFDKEK
   841  LDTIAKVTNK KPITVLEILQ KIRMHVSVPQ CDVFGYFSIE SEIVILIIPV DHYPKALQIE
   901  ACNKEAEKIE SLINSDSPTL ASHVPLSALI ISQVQVSSSV PSAGVRARPS CHSLLLPLSL
   961  GLALHLLWTY N

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RECK can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

ovary: 17 nTPM
blood vessel: 15 nTPM
tongue: 15 nTPM
cervix: 14 nTPM
adipose tissue: 14 nTPM
smooth muscle: 14 nTPM

Single-cell type

fibro-adipogenic progenitors: 155 nCPM
microglia: 153 nCPM
early primary spermatocytes: 138 nCPM
oligodendrocytes: 137 nCPM
breast lactating cells: 123 nCPM
brain excitatory neurons: 118 nCPM

Immune cell

naive CD4 T-cell: 6.3 nTPM
memory CD4 T-cell: 5.2 nTPM
non-classical monocyte: 4.8 nTPM
naive CD8 T-cell: 4.6 nTPM
MAIT T-cell: 4.5 nTPM
memory CD8 T-cell: 4.2 nTPM

Brain region

hippocampal formation: 9.7 nTPM
cerebral cortex: 8.2 nTPM
white matter: 8.2 nTPM
medulla oblongata: 7.6 nTPM
pons: 7.4 nTPM
thalamus: 7.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.67
gnomAD pLI: 0
gnomAD missense Z: 1.54
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Kazal domain
Kazal domain superfamily
Kazal-type serine protease inhibitor domain
Reversion-inducing cysteine-rich protein with Kazal motifs
Reversion-inducing cysteine-rich with Kazal motifs, N-terminal
RECK, EGF-like 2 domain
Reversion-inducing cysteine-rich protein with Kazal, EGF-like 1 domain
Reversion-inducing cysteine-rich protein with Kazal, fibronectin type I module
Reversion-inducing cysteine-rich protein with Kazal, CC4 domain
Reversion-inducing cysteine-rich protein with Kazal, frizzled-like domain
RECK-like, EGF-like 1 domain
Reversion-inducing cysteine-rich with Kazal motifs, N-terminal
RECK, frizzled-like domain
RECK-like, CC4 domain
RECK-like, EGF-like 1 domain
RECK, fibronectin type I module

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RECK in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RECK as an antibody target. Whether an autoantibody or antibody against RECK could matter depends on whether native RECK is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RECK is annotated at the cell surface, where native RECK is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RECK as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...