Seroatlas · Human Serome Atlas

SLC25A37

Mitoferrin-1

Also known as: HT015, MFRN, MFRN1, MFRN1_HUMAN, MSCP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NYZ2
Gene: SLC25A37
Ensembl: ENSG00000147454
Chromosome: 8
Canonical length: 338 aa
Protein class: Metabolic proteins, Predicted intracellular proteins, Transporters
Subcellular location: Mitochondria,Cytosol

OverviewNCBI Gene

SLC25A37 is a solute carrier localized in the mitochondrial inner membrane. It functions as an essential iron importer for the synthesis of mitochondrial heme and iron-sulfur clusters (summary by Chen et al., 2009 [PubMed 19805291]).[supplied by OMIM, Jan 2011]

Canonical amino-acid sequenceUniProt

338 residues, UniProt reviewed canonical sequence.

>Q9NYZ2|SLC25A37
     1  MELRSGSVGS QAVARRMDGD SRDGGGGKDA TGSEDYENLP TSASVSTHMT AGAMAGILEH
    61  SVMYPVDSVK TRMQSLSPDP KAQYTSIYGA LKKIMRTEGF WRPLRGVNVM IMGAGPAHAM
   121  YFACYENMKR TLNDVFHHQG NSHLANGIAG SMATLLHDAV MNPAEVVKQR LQMYNSQHRS
   181  AISCIRTVWR TEGLGAFYRS YTTQLTMNIP FQSIHFITYE FLQEQVNPHR TYNPQSHIIS
   241  GGLAGALAAA ATTPLDVCKT LLNTQENVAL SLANISGRLS GMANAFRTVY QLNGLAGYFK
   301  GIQARVIYQM PSTAISWSVY EFFKYFLTKR QLENRAPY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC25A37 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 6
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 130 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 130 nTPM
duodenum: 48 nTPM
spleen: 46 nTPM
adrenal gland: 42 nTPM
salivary gland: 38 nTPM
prostate: 35 nTPM

Single-cell type

neutrophils: 4,650 nCPM
erythrocytes: 2,304 nCPM
late spermatids: 1,652 nCPM
erythrocyte progenitors: 1,111 nCPM
breast lactating cells: 801 nCPM
early spermatids: 798 nCPM

Immune cell

neutrophil: 58 nTPM
classical monocyte: 3 nTPM
myeloid DC: 2.8 nTPM
eosinophil: 2.7 nTPM
memory B-cell: 2.3 nTPM
naive CD4 T-cell: 2 nTPM

Brain region

cerebral cortex: 29 nTPM
basal ganglia: 20 nTPM
pons: 17 nTPM
thalamus: 17 nTPM
choroid plexus: 17 nTPM
medulla oblongata: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.63
gnomAD pLI: 0.28
gnomAD missense Z: 1.1
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLC25A37 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

ACB10
ABCB10
FECH

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC25A37 as an antibody target. Whether an autoantibody or antibody against SLC25A37 could matter depends on whether native SLC25A37 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC25A37 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC25A37 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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