C2 domain of PTEN tumour-suppressor protein

Definition

This is the C2 domain-like domain, in greek key form, of the PTEN protein, phosphatidyl-inositol triphosphate phosphatase, and it is the C-terminus. This domain may well include a CBR3 loop which means it plays a central role in membrane binding. This domain associates across an extensive interface with the N-terminal phosphatase domain DSPc ([pfam:PF00782]) suggesting that the C2 domain productively positions the catalytic part of the protein onto the membrane PMID:10555148.

9 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (9 proteins: gene, accession, name)

• DNAJC6
• GAK
• PTEN
• TNS1
• TNS2
• TNS3
• TPTE
• TPTE2
• TPTE2P1