Seroatlas · Human Serome Atlas

TPTE

Putative tyrosine-protein phosphatase TPTE

Also known as: CT44, PTEN2, TPTE_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P56180
Gene: TPTE
Ensembl: ENSG00000274391
Chromosome: 21
Canonical length: 551 aa
Protein class: Enzymes, Plasma proteins, Predicted membrane proteins
Subcellular location: Endoplasmic reticulum,Cytosol

OverviewNCBI Gene

This gene encodes a PTEN-related tyrosine phosphatase which may play a role in the signal transduction pathways of the endocrine or spermatogenic function of the testis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

Canonical amino-acid sequenceUniProt

551 residues, UniProt reviewed canonical sequence.

>P56180|TPTE
     1  MNESPDPTDL AGVIIELGPN DSPQTSEFKG ATEEAPAKES PHTSEFKGAA RVSPISESVL
    61  ARLSKFEVED AENVASYDSK IKKIVHSIVS SFAFGLFGVF LVLLDVTLIL ADLIFTDSKL
   121  YIPLEYRSIS LAIALFFLMD VLLRVFVERR QQYFSDLFNI LDTAIIVILL LVDVVYIFFD
   181  IKLLRNIPRW THLLRLLRLI ILLRIFHLFH QKRQLEKLIR RRVSENKRRY TRDGFDLDLT
   241  YVTERIIAMS FPSSGRQSFY RNPIKEVVRF LDKKHRNHYR VYNLCSERAY DPKHFHNRVV
   301  RIMIDDHNVP TLHQMVVFTK EVNEWMAQDL ENIVAIHCKG GTDRTGTMVC AFLIASEICS
   361  TAKESLYYFG ERRTDKTHSE KFQGVKTPSQ KRYVAYFAQV KHLYNWNLPP RRILFIKHFI
   421  IYSIPRYVRD LKIQIEMEKK VVFSTISLGK CSVLDNITTD KILIDVFDGL PLYDDVKVQF
   481  FYSNLPTYYD NCSFYFWLHT SFIENNRLYL PKNELDNLHK QKARRIYPSD FAVEILFGEK
   541  MTSSDVVAGS D

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TPTE can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 3
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 106 nTPM

Expression across tissuesHPA

Tissue

testis: 106 nTPM
placenta: 0.5 nTPM
skin: 0.3 nTPM
epididymis: 0.2 nTPM
ovary: 0.1 nTPM
salivary gland: 0.1 nTPM

Single-cell type

early primary spermatocytes: 16 nCPM
late primary spermatocytes: 4.4 nCPM
podocytes: 3.1 nCPM
loop of henle epithelial cells: 2.8 nCPM
undifferentiated spermatogonia: 2.7 nCPM
distal convoluted tubule cells: 2.3 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 2.5 nTPM
medulla oblongata: 1.5 nTPM
pons: 1.5 nTPM
cerebral cortex: 1.2 nTPM
hypothalamus: 1.2 nTPM
midbrain: 1.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.45
gnomAD pLI: 0
gnomAD missense Z: -1.29

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TPTE as an antibody target. Whether an autoantibody or antibody against TPTE could matter depends on whether native TPTE is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TPTE is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TPTE as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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