Seroatlas · Human Serome Atlas

TPTE2

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2

Also known as: TPIP, TPTE2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6XPS3
Gene: TPTE2
Ensembl: ENSG00000132958
Chromosome: 13
Canonical length: 522 aa
Protein class: Enzymes, Metabolic proteins, Plasma proteins, Predicted membrane proteins
Subcellular location: Endoplasmic reticulum,Cytosol

OverviewNCBI Gene

TPIP is a member of a large class of membrane-associated phosphatases with substrate specificity for the 3-position phosphate of inositol phospholipids.[supplied by OMIM, Jul 2002]

Canonical amino-acid sequenceUniProt

522 residues, UniProt reviewed canonical sequence.

>Q6XPS3|TPTE2
     1  MNESPQTNEF KGTTEEAPAK ESPHTSEFKG AALVSPISKS MLERLSKFEV EDAENVASYD
    61  SKIKKIVHSI VSSFAFGIFG VFLVLLDVTL LLADLIFTDS KLYIPLEYRS ISLAIGLFFL
   121  MDVLLRVFVE GRQQYFSDLF NILDTAIIVI PLLVDVIYIF FDIKLLRNIP RWTHLVRLLR
   181  LIILIRIFHL LHQKRQLEKL MRRLVSENKR RYTRDGFDLD LTYVTERIIA MSFPSSGRQS
   241  FYRNPIEEVV RFLDKKHRNH YRVYNLCSER AYDPKHFHNR VSRIMIDDHN VPTLHEMVVF
   301  TKEVNEWMAQ DLENIVAIHC KGGKGRTGTM VCALLIASEI FLTAEESLYY FGERRTNKTH
   361  SNKFQGVETP SQNRYVGYFA QVKHLYNWNL PPRRILFIKR FIIYSIRGDV CDLKVQVVME
   421  KKVVFSSTSL GNCSILHDIE TDKILINVYD GPPLYDDVKV QFFSSNLPKY YDNCPFFFWF
   481  NTSFIQNNRL CLPRNELDNP HKQKAWKIYP PEFAVEILFG EK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TPTE2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 3
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 6.9 nTPM

Expression across tissuesHPA

Tissue

testis: 6.9 nTPM
duodenum: 0.5 nTPM
basal ganglia: 0.4 nTPM
retina: 0.4 nTPM
small intestine: 0.4 nTPM
tonsil: 0.4 nTPM

Single-cell type

early primary spermatocytes: 135 nCPM
late primary spermatocytes: 113 nCPM
plasma cells: 36 nCPM
early spermatids: 30 nCPM
sertoli cells: 27 nCPM
undifferentiated spermatogonia: 27 nCPM

Immune cell

neutrophil: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebellum: 1.3 nTPM
white matter: 1.3 nTPM
pons: 1.2 nTPM
medulla oblongata: 1.1 nTPM
hypothalamus: 1 nTPM
cerebral cortex: 0.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.95
gnomAD pLI: 0
gnomAD missense Z: 0.05
DepMap mean gene effect: -0.16
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

phosphatidylinositol biosynthetic process

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TPTE2 as an antibody target. Whether an autoantibody or antibody against TPTE2 could matter depends on whether native TPTE2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TPTE2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TPTE2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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