SEFIR domain

Definition

This family comprises IL17 receptors (IL17Rs, e.g. [swissprot:Q60943]) and SEF proteins (e.g. [swissprot:Q8QHJ9]). The latter are feedback inhibitors of FGF signalling and are also thought to be receptors. Due to its similarity to the TIR domain ([pfam:PF01582]), the SEFIR region is thought to be involved in homotypic interactions with other SEFIR/TIR-domain-containing proteins. Thus, SEFs and IL17Rs may be involved in TOLL/IL1R-like signalling pathways PMID:12765832.

6 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (6 proteins: gene, accession, name)

• IL17RA
• IL17RB
• IL17RC
• IL17RD
• IL17RE
• TRAF3IP2