Seroatlas · Human Serome Atlas

IL17RE

Interleukin-17 receptor E

Also known as: FLJ23658, I17RE_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8NFR9
Gene
IL17RE
Ensembl
ENSG00000163701
Chromosome
3
Canonical length
667 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Secretome location
Intracellular and membrane

OverviewNCBI Gene

This gene encodes a transmembrane protein that functions as the receptor for interleukin-17C. The encoded protein signals to downstream components of the mitogen activated protein kinase (MAPK) pathway. Activity of this protein is important in the immune response to bacterial pathogens. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2013]

Canonical amino-acid sequenceUniProt

667 residues, UniProt reviewed canonical sequence.

>Q8NFR9|IL17RE
     1  MGSSRLAALL LPLLLIVIDL SDSAGIGFRH LPHWNTRCPL ASHTDDSFTG SSAYIPCRTW
    61  WALFSTKPWC VRVWHCSRCL CQHLLSGGSG LQRGLFHLLV QKSKKSSTFK FYRRHKMPAP
   121  AQRKLLPRRH LSEKSHHISI PSPDISHKGL RSKRTQPSDP ETWESLPRLD SQRHGGPEFS
   181  FDLLPEARAI RVTISSGPEV SVRLCHQWAL ECEELSSPYD VQKIVSGGHT VELPYEFLLP
   241  CLCIEASYLQ EDTVRRKKCP FQSWPEAYGS DFWKSVHFTD YSQHTQMVMA LTLRCPLKLE
   301  AALCQRHDWH TLCKDLPNAT ARESDGWYVL EKVDLHPQLC FKFSFGNSSH VECPHQTGSL
   361  TSWNVSMDTQ AQQLILHFSS RMHATFSAAW SLPGLGQDTL VPPVYTVSQA RGSSPVSLDL
   421  IIPFLRPGCC VLVWRSDVQF AWKHLLCPDV SYRHLGLLIL ALLALLTLLG VVLALTCRRP
   481  QSGPGPARPV LLLHAADSEA QRRLVGALAE LLRAALGGGR DVIVDLWEGR HVARVGPLPW
   541  LWAARTRVAR EQGTVLLLWS GADLRPVSGP DPRAAPLLAL LHAAPRPLLL LAYFSRLCAK
   601  GDIPPPLRAL PRYRLLRDLP RLLRALDARP FAEATSWGRL GARQRRQSRL ELCSRLEREA
   661  ARLADLG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IL17RE can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
30 nTPM

Expression across tissuesHPA

Tissue

  • skin: 30 nTPM
  • duodenum: 20 nTPM
  • small intestine: 19 nTPM
  • stomach: 16 nTPM
  • colon: 16 nTPM
  • rectum: 13 nTPM

Single-cell type

  • enterocytes: 103 nCPM
  • goblet cells: 97 nCPM
  • colonocytes: 88 nCPM
  • foveolar cells: 84 nCPM
  • paneth cells: 58 nCPM
  • enteric transient amplifying cells: 51 nCPM

Immune cell

  • basophil: 0.8 nTPM
  • memory CD8 T-cell: 0.5 nTPM
  • MAIT T-cell: 0.3 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM

Brain region

  • pons: 4.5 nTPM
  • cerebellum: 4 nTPM
  • basal ganglia: 2.9 nTPM
  • medulla oblongata: 1.4 nTPM
  • hypothalamus: 1.3 nTPM
  • amygdala: 0.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.77
gnomAD pLI
0
gnomAD missense Z
1.05
DepMap mean gene effect
0.08
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IL17RE as an antibody target. Whether an autoantibody or antibody against IL17RE could matter depends on whether native IL17RE is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IL17RE is annotated at the cell surface, where native IL17RE is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IL17RE as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IL17RE. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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