Seroatlas · Human Serome Atlas

IL17RA

Interleukin-17 receptor A

Also known as: CD217, CDw217, hIL-17R, I17RA_HUMAN, IL-17RA, IL17R

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96F46
Gene: IL17RA
Ensembl: ENSG00000177663
Chromosome: 22
Canonical length: 866 aa
Protein class: CD markers, Disease related genes, Human disease related genes, Predicted membrane proteins, Predicted secreted proteins
Subcellular location: Nucleoplasm,Cytosol
Secretome location: Secreted to blood
Quaternary structure: Homodimer

OverviewNCBI Gene

Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2014]

Canonical amino-acid sequenceUniProt

866 residues, UniProt reviewed canonical sequence.

>Q96F46|IL17RA
     1  MGAARSPPSA VPGPLLGLLL LLLGVLAPGG ASLRLLDHRA LVCSQPGLNC TVKNSTCLDD
    61  SWIHPRNLTP SSPKDLQIQL HFAHTQQGDL FPVAHIEWTL QTDASILYLE GAELSVLQLN
   121  TNERLCVRFE FLSKLRHHHR RWRFTFSHFV VDPDQEYEVT VHHLPKPIPD GDPNHQSKNF
   181  LVPDCEHARM KVTTPCMSSG SLWDPNITVE TLEAHQLRVS FTLWNESTHY QILLTSFPHM
   241  ENHSCFEHMH HIPAPRPEEF HQRSNVTLTL RNLKGCCRHQ VQIQPFFSSC LNDCLRHSAT
   301  VSCPEMPDTP EPIPDYMPLW VYWFITGISI LLVGSVILLI VCMTWRLAGP GSEKYSDDTK
   361  YTDGLPAADL IPPPLKPRKV WIIYSADHPL YVDVVLKFAQ FLLTACGTEV ALDLLEEQAI
   421  SEAGVMTWVG RQKQEMVESN SKIIVLCSRG TRAKWQALLG RGAPVRLRCD HGKPVGDLFT
   481  AAMNMILPDF KRPACFGTYV VCYFSEVSCD GDVPDLFGAA PRYPLMDRFE EVYFRIQDLE
   541  MFQPGRMHRV GELSGDNYLR SPGGRQLRAA LDRFRDWQVR CPDWFECENL YSADDQDAPS
   601  LDEEVFEEPL LPPGTGIVKR APLVREPGSQ ACLAIDPLVG EEGGAAVAKL EPHLQPRGQP
   661  APQPLHTLVL AAEEGALVAA VEPGPLADGA AVRLALAGEG EACPLLGSPG AGRNSVLFLP
   721  VDPEDSPLGS STPMASPDLL PEDVREHLEG LMLSLFEQSL SCQAQGGCSR PAMVLTDPHT
   781  PYEEEQRQSV QSDQGYISRS SPQPPEGLTE MEEEEEEEQD PGKPALPLSP EDLESLRSLQ
   841  RQLLFRQLQK NSGWDTMGSE SEGPSA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IL17RA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 33 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 33 nTPM
spleen: 16 nTPM
thymus: 15 nTPM
lung: 9.6 nTPM
appendix: 9.1 nTPM
adipose tissue: 8.6 nTPM

Single-cell type

neutrophils: 1,157 nCPM
neutrophil progenitors: 579 nCPM
monocyte progenitors: 390 nCPM
microglia: 224 nCPM
monocytes: 209 nCPM
macrophages: 109 nCPM

Immune cell

neutrophil: 15 nTPM
eosinophil: 9.2 nTPM
basophil: 7.9 nTPM
classical monocyte: 7.1 nTPM
myeloid DC: 4 nTPM
non-classical monocyte: 3.6 nTPM

Brain region

basal ganglia: 28 nTPM
white matter: 24 nTPM
medulla oblongata: 24 nTPM
pons: 21 nTPM
choroid plexus: 19 nTPM
thalamus: 19 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about IL17RA.

Disease | AllUniProt

Conditions IL17RA is implicated in, by any mechanism.

Immunodeficiency 51 (IMD51) MIM:613953

Disease | GeneticClinVar

28 pathogenic / likely-pathogenic of 1,025 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Immunodeficiency 51
Psoriasis
Chronic mucocutaneous candidiasis

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.63
gnomAD pLI: 0
gnomAD missense Z: -0.79
DepMap mean gene effect: -0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IL17RA in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IL17RA as an antibody target. Whether an autoantibody or antibody against IL17RA could matter depends on whether native IL17RA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IL17RA is annotated at the cell surface, where native IL17RA is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Source-annotated serology context

The source annotations explicitly mention antibody, autoantibody, autoantigen, or autoimmune context. This is biological context, not study-specific reactivity.

Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis.

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