Seroatlas · Human Serome Atlas

TRAF3IP2

E3 ubiquitin ligase TRAF3IP2

Also known as: ACT1, C6orf2, C6orf4, C6orf5, C6orf6, CIKS, CIKS_HUMAN, DKFZP586G0522

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O43734
Gene
TRAF3IP2
Ensembl
ENSG00000056972
Chromosome
6
Canonical length
574 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Golgi apparatus,Vesicles

OverviewNCBI Gene

This gene encodes a protein involved in regulating responses to cytokines by members of the Rel/NF-kappaB transcription factor family. These factors play a central role in innate immunity in response to pathogens, inflammatory signals and stress. This gene product interacts with TRAF proteins (tumor necrosis factor receptor-associated factors) and either I-kappaB kinase or MAP kinase to activate either NF-kappaB or Jun kinase. Several alternative transcripts encoding different isoforms have been identified. Another transcript, which does not encode a protein and is transcribed in the opposite orientation, has been identified. Overexpression of this transcript has been shown to reduce expression of at least one of the protein encoding transcripts, suggesting it has a regulatory role in the expression of this gene. [provided by RefSeq, Aug 2009]

Canonical amino-acid sequenceUniProt

574 residues, UniProt reviewed canonical sequence.

>O43734|TRAF3IP2
     1  MPPQLQETRM NRSIPVEVDE SEPYPSQLLK PIPEYSPEEE SEPPAPNIRN MAPNSLSAPT
    61  MLHNSSGDFS QAHSTLKLAN HQRPVSRQVT CLRTQVLEDS EDSFCRRHPG LGKAFPSGCS
   121  AVSEPASESV VGALPAEHQF SFMEKRNQWL VSQLSAASPD TGHDSDKSDQ SLPNASADSL
   181  GGSQEMVQRP QPHRNRAGLD LPTIDTGYDS QPQDVLGIRQ LERPLPLTSV CYPQDLPRPL
   241  RSREFPQFEP QRYPACAQML PPNLSPHAPW NYHYHCPGSP DHQVPYGHDY PRAAYQQVIQ
   301  PALPGQPLPG ASVRGLHPVQ KVILNYPSPW DHEERPAQRD CSFPGLPRHQ DQPHHQPPNR
   361  AGAPGESLEC PAELRPQVPQ PPSPAAVPRP PSNPPARGTL KTSNLPEELR KVFITYSMDT
   421  AMEVVKFVNF LLVNGFQTAI DIFEDRIRGI DIIKWMERYL RDKTVMIIVA ISPKYKQDVE
   481  GAESQLDEDE HGLHTKYIHR MMQIEFIKQG SMNFRFIPVL FPNAKKEHVP TWLQNTHVYS
   541  WPKNKKNILL RLLREEEYVA PPRGPLPTLQ VVPL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRAF3IP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.59
Highest tissue expression
33 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 33 nTPM
  • skin: 28 nTPM
  • epididymis: 28 nTPM
  • fallopian tube: 27 nTPM
  • endometrium: 25 nTPM
  • esophagus: 25 nTPM

Single-cell type

  • epididymal basal cells: 279 nCPM
  • esophageal apical cells: 123 nCPM
  • endometrial glandular cells: 103 nCPM
  • epicardial cells: 91 nCPM
  • epididymal efferent duct ciliated cells: 88 nCPM
  • fallopian secretory cells: 84 nCPM

Immune cell

  • basophil: 26 nTPM
  • T-reg: 13 nTPM
  • MAIT T-cell: 8.6 nTPM
  • naive B-cell: 6.7 nTPM
  • naive CD8 T-cell: 6.1 nTPM
  • memory CD4 T-cell: 5.9 nTPM

Brain region

  • midbrain: 38 nTPM
  • medulla oblongata: 37 nTPM
  • hypothalamus: 36 nTPM
  • pons: 33 nTPM
  • cerebellum: 32 nTPM
  • cerebral cortex: 32 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TRAF3IP2.

Disease | AllUniProt

Conditions TRAF3IP2 is implicated in, by any mechanism.

Disease | GeneticClinVar

21 pathogenic / likely-pathogenic of 326 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Candidiasis, familial, 8
  • Discoid lupus erythematosus
  • Melanoma
  • Psoriasis 13, susceptibility to

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.98
gnomAD pLI
0
gnomAD missense Z
1.63
DepMap mean gene effect
0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRAF3IP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRAF3IP2 as an antibody target. Whether an autoantibody or antibody against TRAF3IP2 could matter depends on whether native TRAF3IP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRAF3IP2 is annotated at the cell surface, where native TRAF3IP2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TRAF3IP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TRAF3IP2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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