Serine incorporator (Serinc)

Definition

This is a family of eukaryotic membrane proteins which incorporate serine into membranes and facilitate the synthesis of the serine-derived lipids phosphatidylserine and sphingolipid PMID:16120614. Members of this family contain 11 transmembrane domains and form intracellular complexes with key enzymes involved in serine and sphingolipid biosynthesis PMID:16120614. SERINC3 (also known as TDE1) and SERINC5 are restriction factors required to restrict infectivity of lentiviruses, such as HIV-1; they act by inhibiting an early step of viral infection and they impair the penetration of the viral particle into the cytoplasm [[cite:PMID:37474505],[cite:PMID:39271159]]. SERINC3/5 are non-specific lipid transporters for phosphatidylserine, phosphatidylcholine, and phosphatidylethanolamine that functions as a scramblase that flips lipids in both directions across the membrane.

5 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (5 proteins: gene, accession, name)

• SERINC1
• SERINC2
• SERINC3
• SERINC4
• SERINC5