Seroatlas · Human Serome Atlas

SERINC3

Serine incorporator 3

Also known as: AIGP1, DIFF33, SBBI99, SERC3_HUMAN, TDE, TDE1, TMS-1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q13530
Gene: SERINC3
Ensembl: ENSG00000132824
Chromosome: 20
Canonical length: 473 aa
Protein class: Predicted membrane proteins, Transporters

OverviewNCBI Gene

Enables phospholipid scramblase activity. Involved in antiviral innate immune response and plasma membrane phospholipid scrambling. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

473 residues, UniProt reviewed canonical sequence.

>Q13530|SERINC3
     1  MGAVLGVFSL ASWVPCLCSG ASCLLCSCCP NSKNSTVTRL IYAFILLLST VVSYIMQRKE
    61  METYLKKIPG FCEGGFKIHE ADINADKDCD VLVGYKAVYR ISFAMAIFFF VFSLLMFKVK
   121  TSKDLRAAVH NGFWFFKIAA LIGIMVGSFY IPGGYFSSVW FVVGMIGAAL FILIQLVLLV
   181  DFAHSWNESW VNRMEEGNPR LWYAALLSFT SAFYILSIIC VGLLYTYYTK PDGCTENKFF
   241  ISINLILCVV ASIISIHPKI QEHQPRSGLL QSSLITLYTM YLTWSAMSNE PDRSCNPNLM
   301  SFITRITAPT LAPGNSTAVV PTPTPPSKSG SLLDSDNFIG LFVFVLCLLY SSIRTSTNSQ
   361  VDKLTLSGSD SVILGDTTTS GASDEEDGQP RRAVDNEKEG VQYSYSLFHL MLCLASLYIM
   421  MTLTSWYSPD AKFQSMTSKW PAVWVKISSS WVCLLLYVWT LVAPLVLTSR DFS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SERINC3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 8
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 110 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 110 nTPM
placenta: 109 nTPM
testis: 103 nTPM
parathyroid gland: 101 nTPM
liver: 87 nTPM
adrenal gland: 86 nTPM

Single-cell type

late spermatids: 970 nCPM
neutrophils: 767 nCPM
platelets: 374 nCPM
late primary spermatocytes: 264 nCPM
esophageal apical cells: 262 nCPM
syncytiotrophoblasts: 221 nCPM

Immune cell

basophil: 217 nTPM
neutrophil: 178 nTPM
total PBMC: 138 nTPM
eosinophil: 120 nTPM
non-classical monocyte: 114 nTPM
NK-cell: 111 nTPM

Brain region

white matter: 148 nTPM
cerebral cortex: 147 nTPM
pons: 139 nTPM
hypothalamus: 139 nTPM
hippocampal formation: 138 nTPM
basal ganglia: 134 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.41
gnomAD pLI: 0.78
gnomAD missense Z: 0.16
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SERINC3 as an antibody target. Whether an autoantibody or antibody against SERINC3 could matter depends on whether native SERINC3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SERINC3 is annotated at the cell surface, where native SERINC3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SERINC3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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