Seroatlas · Human Serome Atlas

SERINC5

Serine incorporator 5

Also known as: C5orf12, SERC5_HUMAN, TPO1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86VE9
Gene: SERINC5
Ensembl: ENSG00000164300
Chromosome: 5
Canonical length: 423 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Vesicles,Plasma membrane,Centrosome,Cytosol

OverviewNCBI Gene

Enables phospholipid scramblase activity. Involved in antiviral innate immune response and plasma membrane phospholipid scrambling. Located in several cellular components, including centrosome; cytosol; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

423 residues, UniProt reviewed canonical sequence.

>Q86VE9|SERINC5
     1  MSAQCCAGQL ACCCGSAGCS LCCDCCPRIR QSLSTRFMYA LYFILVVVLC CIMMSTTVAH
    61  KMKEHIPFFE DMCKGIKAGD TCEKLVGYSA VYRVCFGMAC FFFIFCLLTL KINNSKSCRA
   121  HIHNGFWFFK LLLLGAMCSG AFFIPDQDTF LNAWRYVGAV GGFLFIGIQL LLLVEFAHKW
   181  NKNWTAGTAS NKLWYASLAL VTLIMYSIAT GGLVLMAVFY TQKDSCMENK ILLGVNGGLC
   241  LLISLVAISP WVQNRQPHSG LLQSGVISCY VTYLTFSALS SKPAEVVLDE HGKNVTICVP
   301  DFGQDLYRDE NLVTILGTSL LIGCILYSCL TSTTRSSSDA LQGRYAAPEL EIARCCFCFS
   361  PGGEDTEEQQ PGKEGPRVIY DEKKGTVYIY SYFHFVFFLA SLYVMMTVTN WFNHVRSAFH
   421  LLP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SERINC5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 9
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 43 nTPM

Expression across tissuesHPA

Tissue

liver: 43 nTPM
adrenal gland: 33 nTPM
prostate: 32 nTPM
rectum: 28 nTPM
testis: 27 nTPM
colon: 27 nTPM

Single-cell type

urothelial cells: 1,071 nCPM
endometrial glandular cells: 941 nCPM
prostatic glandular cells: 937 nCPM
sertoli cells: 710 nCPM
endometrial luminal cells: 598 nCPM
prostatic hillock cells: 516 nCPM

Immune cell

naive CD4 T-cell: 23 nTPM
memory CD4 T-cell: 19 nTPM
naive CD8 T-cell: 14 nTPM
basophil: 11 nTPM
classical monocyte: 9.2 nTPM
total PBMC: 7.5 nTPM

Brain region

white matter: 97 nTPM
basal ganglia: 71 nTPM
thalamus: 70 nTPM
midbrain: 65 nTPM
cerebellum: 65 nTPM
medulla oblongata: 64 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.77
gnomAD pLI: 0
gnomAD missense Z: 0.97
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SERINC5 as an antibody target. Whether an autoantibody or antibody against SERINC5 could matter depends on whether native SERINC5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SERINC5 is annotated at the cell surface, where native SERINC5 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SERINC5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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